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Quantification and Progress Over Time of Specific Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 in Breast Milk of Lactating Women Vaccinated With BNT162b2 Pfizer-BioNTech Coronavirus Disease 2019 Vaccine (LacCOVID).
Esteve-Palau, Erika; Gonzalez-Cuevas, Araceli; Guerrero, M Eugenia; Garcia-Terol, Clara; Alvarez, M Carmen; Garcia, Geneva; Moreno, Encarna; Medina, Francisco; Casadevall, David; Diaz-Brito, Vicens.
  • Esteve-Palau E; Department of Infectious Diseases, Parc Sanitari Sant Joan de Deu, Sant Boi, Barcelona, Spain.
  • Gonzalez-Cuevas A; Department of Microbiology, Parc Sanitari Sant Joan de Deu, Sant Boi, Barcelona, Spain.
  • Guerrero ME; Department of Microbiology, Parc Sanitari Sant Joan de Deu, Sant Boi, Barcelona, Spain.
  • Garcia-Terol C; Department of Obstetrics and Gynecology, Parc Sanitari Sant Joan de Deu, Sant Boi, Barcelona, Spain.
  • Alvarez MC; Department of Infectious Diseases, Parc Sanitari Sant Joan de Deu, Sant Boi, Barcelona, Spain.
  • Garcia G; Department of Infectious Diseases, Parc Sanitari Sant Joan de Deu, Sant Boi, Barcelona, Spain.
  • Moreno E; Department of Infectious Diseases, Parc Sanitari Sant Joan de Deu, Sant Boi, Barcelona, Spain.
  • Medina F; Department of Infectious Diseases, Parc Sanitari Sant Joan de Deu, Sant Boi, Barcelona, Spain.
  • Casadevall D; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.
  • Diaz-Brito V; Department of Infectious Diseases, Parc Sanitari Sant Joan de Deu, Sant Boi, Barcelona, Spain.
Open Forum Infect Dis ; 9(6): ofac239, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: covidwho-1922314
ABSTRACT

Background:

Several observational studies demonstrated the passage of postvaccine antibodies through breast milk in women vaccinated against coronavirus disease 2019 (COVID-19), mostly with messenger RNA (mRNA)-based vaccines, but lacked long-term data.

Methods:

A 6-month prospective cohort study was performed to determine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-induced antibody levels in the breast milk of 33 lactating healthcare workers at different timepoints after mRNA BNT162b2 Pfizer-BioNTech COVID-19 vaccination. Moreover, we examined the correlation of SARS-CoV-2 antibody levels between serum and breast milk, adverse events related to vaccination, and rate of SARS-CoV-2 infections.

Results:

Mothers' median age was 38 (interquartile range [IQR], 36-39) years and 15 (IQR, 10-22) months for infants. Median (IQR) SARS-CoV-2 immunoglobulin G (IgG) spike protein subunit S1 (S1) vaccine-induced levels at different timepoints for serum-milk pairs were 519 (234-937) to 1 (0-2.9) arbitrary units (AU)/mL at 2 weeks after first dose and 18 644 (9923-29 264) to 78 (33.7-128), 12 478 (6870-20 801) to 50.4 (24.3-104), 4094 (2413-8480) to 19.9 (10.8-51.9), 1350 (831-2298) to 8.9 (7.8-31.5) AU/mL at 2, 4, 12 and 24 weeks after second dose, respectively. We observed a positive correlation of antibody levels between serum and breast milk, no serious adverse events related to vaccination, and 2 (6%) COVID-19 vaccine breakthrough infections.

Conclusions:

Women vaccinated with Pfizer-BioNTech transmit antibodies into breast milk with a positive correlation with serum levels. Both decreased over time in a 6-month follow-up.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo de coorte / Estudo observacional / Estudo prognóstico Tópicos: Vacinas Idioma: Inglês Revista: Open Forum Infect Dis Ano de publicação: 2022 Tipo de documento: Artigo País de afiliação: Ofid

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo de coorte / Estudo observacional / Estudo prognóstico Tópicos: Vacinas Idioma: Inglês Revista: Open Forum Infect Dis Ano de publicação: 2022 Tipo de documento: Artigo País de afiliação: Ofid