Assessment of SARS-CoV-2 Infection According to Previous Metabolic Status and Its Association with Mortality and Post-Acute COVID-19.
Nutrients
; 14(14)2022 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1938927
ABSTRACT
BACKGROUND:
SARS-CoV-2 infection was analyzed according to previous metabolic status and its association with mortality and post-acute COVID-19.METHODS:
A population-based observational retrospective study was conducted on a cohort of 110,726 patients aged 12 years or more who were diagnosed with COVID-19 infection between June 1st, 2021, and 28 February 2022 on the island of Gran Canaria, Spain.RESULTS:
In the 347 patients who died, the combination of advanced age, male sex, cancer, immunosuppressive therapy, coronary heart disease, elevated total cholesterol and reduced high-density lipoprotein cholesterol (HDL-C) was strongly predictive of mortality (p < 0.05). In the 555 patients who developed post-acute COVID-19, the persistence of symptoms was most frequent in women, older subjects and patients with obstructive sleep apnea syndrome, asthma, elevated fasting glucose levels or elevated total cholesterol (p < 0.05). A complete vaccination schedule was associated with lower mortality (incidence rate ratio (IRR) 0.5, 95%CI 0.39-0.64; p < 0.05) and post-acute COVID-19 (IRR 0.37, 95%CI 0.31-0.44; p < 0.05).CONCLUSIONS:
Elevated HDL-C and elevated total cholesterol were significantly associated with COVID-19 mortality. Elevated fasting glucose levels and elevated total cholesterol were risk factors for the development of post-acute COVID-19.Palavras-chave
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
COVID-19
Tipo de estudo:
Estudo de coorte
/
Estudo observacional
/
Estudo prognóstico
Tópicos:
Covid persistente
/
Vacinas
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
Nu14142925
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