Association between Interlukine-6 with Serum Ferritin, D-dimer, and Lipid Profiles as Risk Factors in Patients with Coronavirus Disease 2019
NeuroQuantology
; 20(6):1192-1197, 2022.
Artigo
em Inglês
| EMBASE | ID: covidwho-1988587
ABSTRACT
Background:
The current coronavirus disease 2019 (COVID-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has posed a significant public health concern throughout the world, putting millions of people at risk in an increasing number of nations.Due to the development of endothelial dysfunction, coagulopathy, cytokine storm, and plaque instability, COVID-19 is recognized as an independent risk factor for cardiovascular illnesses.The goal of this study was to look at blood levels of interleukin 6 (IL-6), lipid profiles, ferritin, C-reactive protein (CRP), D-dimer, lymphocytes, and neutrophils in COVID-19 patients, as well as the relationship between IL-6 and biochemical predictor values for COVID-19 severity. Materials andMethods:
In this case-control study,total of 60 COVID 19 patients within 1 week of displaying COVID19 symptoms and SARS-CoV-2 specific RT-PCR was verified. of Nasopharyngeal (NP) swab specimen were recruited.ageranged between(30-50 years)To compare the results, (60) apparently healthy persons of the same ages and sexes were included in this study ascontrol group.All of the patents and healthy persons were made to suffer to the estimation of serume IL-6, D-Dimer, CRP, ferritin,lipid profiles, andanthropometric data were analyzed.Results:
Serum IL-6 level was higher in covid-19 patients group compared to healthy control group (812.32± 147.76vs. 148.95± 51.59ng/ mLp = 0.0001). Ferritin,CRP, and D-dimer serum levels were also higher in covid-19 patients compared to control group (p = 0.0001). as well as TC,LDL-C,and VLDL-C When compared to healthy controls, COVID-19 patients exhibited a substantial reduction in the levels studied in this study. We also discovered that IL-6 levels were higher significantly associated with the serum ferritin,D-dimer,TC, LDL-C, and CRP levels.Conclusion:
The level of IL-6 was shown to be the most important predictor of outcome and a useful tool for prognostic assessment. The prevalence of atherogenic dyslipidaemia during infection was linked to a poorer COVID-19 infection outcome in a robust and independent way. Low HDL cholesterol and high triglyceride levels seen in covid-19 patients are strong indicators of the disease's severity. 1.
adult; article; blood clotting disorder; case control study; controlled study; coronavirus disease 2019; cytokine storm; dyslipidemia; endothelial dysfunction; female; ferritin blood level; gene expression; human; human cell; human tissue; lipid fingerprinting; lymphocyte; major clinical study; male; nasopharyngeal swab; neutrophil; nonhuman; pandemic; patent; prevalence; prognostic assessment; protein expression; public health; risk assessment; risk factor; Severe acute respiratory syndrome coronavirus 2; triacylglycerol level; C reactive protein; D dimer; endogenous compound; ferritin; high density lipoprotein cholesterol; interleukin 6; low density lipoprotein cholesterol; very low density lipoprotein cholesterol
Texto completo:
Disponível
Coleções:
Bases de dados de organismos internacionais
Base de dados:
EMBASE
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
NeuroQuantology
Ano de publicação:
2022
Tipo de documento:
Artigo
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