IDF21-0587 Correlation between glycemic profile parameters and chronic complications in patients with diabetic heart disease

ABSTRACT

Background: Glycemic imbalance has long been recognized as a major vascular risk factor, and in the can be considered an authentic vascular condition that accelerates the development of chronic complications and major cardiovascular events in diabetics. Aim: The main aim of this study is to determine the correlation between the deferential glycemic profile parameters in order to assess the linkage of these parameters with cardiovascular risk score and chronic complications. Method: During this Covid pandemic, a cross-sectional descriptive and analytical study was included 384 Algerian diabetic patients (189 men, 205 women) with a 9-month follow-up. The diagnostic criteria for diabetes have been defined according to FID and WHO guidelines. Fasting blood sugar levels, GPP and HbA1c, prevalence of chronic complications and cardiovascular risk score were evaluated. Multifactor statistical analysis was performed by Software R studio (Package for Social science software), significance was set at p < 0,05. Results: The mean ± SD age of the patients was 61.28 ± 10.04 with mean fasting blood sugar (61.28 ± 10.04), PPG (3.59 ± 1.02) and HbA1c (8.67 ± 1.64%). PPG and FPG are positively and significantly correlated with HbA1c (regression curves;Figure 1) with a stronger correlation between FPG and HbA1c (r = 0.698). A significant association between Hb1Ac and cardiovascular risk score was noted in patients at very high risk and those at high risk (p-value <10-3). This clinical adherence was the object of studying the multifactorial relationship between Hb1Ac, dyslipidemia and BMI, the correlation of which was significantly positive with r = 0.852. In view of these results and the emergence of significant links, the correlational study by the application of the Pearson test between the variabilities studied, the risk score and the chronic complications shows that there is a very strong association between PPG, Hb1Ac, cardiovascular risk score and macroangiopathy complication. Likewise, the correlation was also positive but moderately significant between FPG, Hb1Ac, and microangiopathy complications. (Correlation matrix in Figure 2). Discussion: The HbA1c is the essential tool for monitoring diabetic patients, its level reflecting glycemic equilibration. It is widely accepted that the glycemic balance of diabetic patients is a complex “alchemy” involving both changes in fasting blood sugar and changes in postprandial blood glucose. The study demonstrated the link between these three parameters and determined its relationship to chronic complications. In this way, glycemic balancing reduces the micro-vascular complications of diabetic patients.