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Relative Effectiveness of COVID-19 Vaccination in Healthcare Workers: 3-Dose Versus 2-Dose Vaccination.
Kim, Sung Ran; Kang, Hyeon Jeong; Jeong, Hye Rin; Jang, Su Yeon; Lee, Jae Eun; Kim, Da Eun; Lee, Hae Ry; Cho, Min Hee; Noh, Ji Yun; Cheong, Hee Jin; Kim, Woo Joo; Song, Joon Young.
  • Kim SR; Infection Control Team, Korea University Guro Hospital, Seoul, Korea.
  • Kang HJ; Infection Control Team, Korea University Guro Hospital, Seoul, Korea.
  • Jeong HR; Infection Control Team, Korea University Guro Hospital, Seoul, Korea.
  • Jang SY; Infection Control Team, Korea University Guro Hospital, Seoul, Korea.
  • Lee JE; Infection Control Team, Korea University Guro Hospital, Seoul, Korea.
  • Kim DE; Infection Control Team, Korea University Guro Hospital, Seoul, Korea.
  • Lee HR; Infection Control Team, Korea University Guro Hospital, Seoul, Korea.
  • Cho MH; Infection Control Team, Korea University Guro Hospital, Seoul, Korea.
  • Noh JY; Infection Control Team, Korea University Guro Hospital, Seoul, Korea.
  • Cheong HJ; Division of Infectious Disease, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
  • Kim WJ; Vaccine Innovation Center-KU Medicine (VIC-K), Seoul, Korea.
  • Song JY; Infection Control Team, Korea University Guro Hospital, Seoul, Korea.
J Korean Med Sci ; 37(35): e267, 2022 Sep 05.
Artigo em Inglês | MEDLINE | ID: covidwho-2022641
ABSTRACT
The omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to have high infectivity and is more likely to evade vaccine immunity. However, booster vaccination is expected to strengthen cross-reactive immunity, thereby increasing the vaccine effectiveness (VE). This study aimed to evaluate the relative VE of the 3-dose (booster) vaccination compared with the 2-dose primary series vaccination in healthcare workers during omicron variant-dominant periods. During the omicron-dominant period from February 1, 2022 to February 28, 2022, a 11 matched case-control study was conducted. Healthcare workers with positive SARS-CoV-2 test results were classified as positive cases, whereas those with negative results served as controls. Compared with the 2-dose primary series vaccination, booster vaccination with mRNA vaccine showed moderate VE (53.1%). However, in multivariate analysis including the time elapsed after vaccination, the significant VE disappeared, reflecting the impact of recent vaccination rather than the third dose itself.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Vacinas contra COVID-19 / COVID-19 Tipo de estudo: Estudo experimental / Estudo observacional / Ensaios controlados aleatorizados Tópicos: Vacinas / Variantes Limite: Humanos Idioma: Inglês Revista: J Korean Med Sci Assunto da revista: Medicina Ano de publicação: 2022 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Vacinas contra COVID-19 / COVID-19 Tipo de estudo: Estudo experimental / Estudo observacional / Ensaios controlados aleatorizados Tópicos: Vacinas / Variantes Limite: Humanos Idioma: Inglês Revista: J Korean Med Sci Assunto da revista: Medicina Ano de publicação: 2022 Tipo de documento: Artigo