Characteristics, management and outcomes of thirty COVID-19 ARDS patients supported with veno-venous extracorporeal membrane oxygenation at Rikshospitalet, Oslo University Hospital
Acta Anaesthesiologica Scandinavica
; 67(4):549-550, 2023.
Artigo
em Inglês
| EMBASE | ID: covidwho-20232838
ABSTRACT
Background:
We reviewed patients with COVID-19 ARDS managed with VV-ECMO support at our center from March 2020 until February 2022. Material(s) and Method(s) We extracted data from electronic health records (Metavision and DIPS). We registered premorbid health status, ventilator-settings before initiation of ECMO, the time-course, and hospital mortality. Result(s) Thirty patients were managed at our hospital, with a median age of 57.2 years (28-65) and median BMI 28 (22-40). No patient had any serious comorbidity. Twenty-two patients received non-invasive ventilation prior to intubation (1-10 days). The median time on ventilator were 8.0 days (1-19) prior to ECMO and median tidal volume was 5.8 mL/kg PBW (3.1-7.5). Hypoxemia (median PaO2-FiO2 ratio 8 kPa, range 6-12 kPa) and hypercapnia (median PaCO2 11.9 kPa, range 4.2-18.5) [SEP1] despite lung protective ventilation were the main indications for VV-ECMO. Two patients had severe respiratory acidosis without hypoxemia. 18 patients developed serious complications while managed with ECMO (acute renal failure, clinically significant bleeding, sepsis, right ventricular heart failure, dislocation of cannulae). Seven patients received renal replacement therapy. Sixteen patients (53%) died. Thirteen patients (43%) died on ECMO, three (10%) after weaning, Twelve (40%) were discharged from hospital, two are currently in ICU (7%). The median duration of ECMO and ventilator treatment, was 27 (6-50) and 37 (9-78) days, respectively. Conclusion(s) Management of patients with COVID-19 ARDS with VV-ECMO is very resource-intensive, and accompanied by serious complications and high mortality. In-hospital mortality in our cohort was 53%, which is comparable with reports from other centers. However, the duration of ECMO, and pre-ECMO mechanical ventilation, were longer than typically reported.
acute kidney failure; adult; adult respiratory distress syndrome; arterial carbon dioxide tension; artificial ventilation; bleeding; body mass; cannula; case report; clinical article; comorbidity; complication; conference abstract; coronavirus disease 2019; dislocation; electronic health record; female; health status; heart right ventricle failure; Horowitz index; hospital mortality; human; hypercapnia; hypoxemia; in-hospital mortality; intubation; male; middle aged; mortality; noninvasive ventilation; outcome assessment; protective ventilation; renal replacement therapy; respiratory acidosis; sepsis; tidal volume; university hospital; veno-venous ECMO; ventilator; weaning
Texto completo:
Disponível
Coleções:
Bases de dados de organismos internacionais
Base de dados:
EMBASE
Tipo de estudo:
Estudo de coorte
/
Estudo observacional
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Acta Anaesthesiologica Scandinavica
Ano de publicação:
2023
Tipo de documento:
Artigo
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