Imbalanced brain connectome: A possible link behind functional somatic disorders, multiple chemical sensitivity, and long COVID patients
Journal of Psychosomatic Research
; Conference: 10th annual scientific conference of the European Association of Psychosomatic Medicine (EAPM). Wroclaw Poland. 169 (no pagination), 2023.
Artigo
em Inglês
| EMBASE | ID: covidwho-20236441
ABSTRACT
Background:
Functional Somatic Disorders (FSDs) are characterized by persistent physical symptoms that cannot be explained by other somatic or psychiatric conditions. Multiple Chemical Sensitivity (MCS) is a non-allergic FSD characterized by odour intolerance and various somatic symptoms being attributed to the influence of toxic environmental chemicals in low, usually harmless doses. The pathophysiology of FSDs are still not clear. Smell and taste complaints were also among the notable symptoms characterizing the covid epidemic and the latest evidence suggests overlaps between long COVID and FSDs. Method(s) The study includes advanced analysis of MRI-derived functional and structural connectomes acquired on a 3 T MR scanner. Furthermore, it includes questionnaires and paraclinical tests, e.g. the Sniffin' Stick olfactory test, Mini-Mental State Examination, and Sino-Nasal Outcome test 22. The pilot part of the project included 6 MCS patients who were compared with 6 matched healthy participants. Later follow-up included analysis of 8 multiorgan FSD and 4 post-COVID patients. Result(s) The MCS group showed important brain structural connectivity differences in 34 tracts. Notably, for MCS patients, the olfactory cortex (especially in the right hemisphere) showed decreased connectivity with regions in the emotional system. Conclusion(s) We plan to extend these findings with whole-brain modelling of the functional connectivity in the patient groups. Long-term this could be used as a 'fingerprint' which could help with diagnosis and treatment monitoring in FSDs as well as with new diagnoses such as long-COVID.Copyright © 2023
adult; clinical article; conference abstract; connectome; controlled study; coronavirus disease 2019; epidemic; female; follow up; functional connectivity; human; long COVID; male; Mini Mental State Examination; MRI scanner; multiple chemical sensitivity; nuclear magnetic resonance imaging; odor; olfactory cortex; questionnaire; right hemisphere; sino-nasal outcome test-22; structure activity relation
Texto completo:
Disponível
Coleções:
Bases de dados de organismos internacionais
Base de dados:
EMBASE
Tipo de estudo:
Estudo de coorte
/
Estudo experimental
/
Estudo observacional
/
Estudo prognóstico
/
Ensaios controlados aleatorizados
Tópicos:
Covid persistente
Idioma:
Inglês
Revista:
Journal of Psychosomatic Research
Ano de publicação:
2023
Tipo de documento:
Artigo
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