Mechanisms and implications of COVID-19 transport into neural tissue
COVID-19 in Alzheimer's Disease and Dementia
; : 123-132, 2023.
Artigo
em Inglês
| Scopus | ID: covidwho-20236867
ABSTRACT
The neuropathogenicity of COVID-19 was reported shortly after detection of the virus when patients began reporting symptoms of diminished taste and smell, headaches, mental status changes, and more. As the virus spread, increasing data on viral symptoms in conjunction with novel theories on COVID-19 virulence factors indicated that the virus had neurotropic properties. Several mechanisms have been proposed detailing severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2) transport past the blood–brain barrier and into neural tissue. This chapter offers a comprehensive review of possible neurotropic mechanisms including transport via the angiotensin-converting enzyme 2 (ACE-2) receptor, transportation directly past or through the blood–brain barrier, transsynaptic neuronal transfer, and olfactory conduction. © 2023 Elsevier Inc. All rights reserved.
Texto completo:
Disponível
Coleções:
Bases de dados de organismos internacionais
Base de dados:
Scopus
Idioma:
Inglês
Revista:
COVID-19 in Alzheimer's Disease and Dementia
Ano de publicação:
2023
Tipo de documento:
Artigo
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