Causal relationships between COVID-19 and osteoporosis: a two-sample Mendelian randomization study in European population.
Front Public Health
; 11: 1122095, 2023.
Artigo
em Inglês
| MEDLINE | ID: covidwho-20245267
ABSTRACT
Introduction:
The causal relationship between Coronavirus disease 2019 (COVID-19) and osteoporosis (OP) remains uncertain. We aimed to assess the effect of COVID-19 severity (severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, COVID-19 hospitalization, and severe COVID-19) on OP by a two-sample Mendelian randomization (MR) study.Methods:
We conducted a two-sample MR analysis using publicly available genome-wide association study (GWAS) data. Inverse variance weighting (IVW) was used as the main analysis method. Four complementary methods were used for our MR analysis, which included the MR-Egger regression method, the weighted median method, the simple mode method, and the weighted mode method. We utilized the MR-Egger intercept test and MR pleiotropy residual sum and outlier (MR-PRESSO) global test to identify the presence of horizontal pleiotropy. Cochran's Q statistics were employed to assess the existence of instrument heterogeneity. We conducted a sensitivity analysis using the leave-one-out method.Results:
The primary results of IVW showed that COVID-19 severity was not statistically related to OP (SARS-CoV-2 infection OR (95% CI) = 0.998 (0.995 ~ 1.001), p = 0.201403; COVID-19 hospitalization OR (95% CI) =1.001 (0.999 ~ 1.003), p = 0.504735; severe COVID-19 OR (95% CI) = 1.000 (0.998 ~ 1.001), p = 0.965383). In addition, the MR-Egger regression, weighted median, simple mode and weighted mode methods showed consistent results. The results were robust under all sensitivity analyses.Conclusion:
The results of the MR analysis provide preliminary evidence that a genetic causal link between the severity of COVID-19 and OP may be absent.Palavras-chave
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Osteoporose
/
COVID-19
Tipo de estudo:
Estudo experimental
/
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Front Public Health
Ano de publicação:
2023
Tipo de documento:
Artigo
País de afiliação:
Fpubh.2023.1122095
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