Sero-prevalence of anti-SARS-CoV-2 Antibodies in Addis Ababa, Ethiopia
The Ethiopian Journal of Health Development
; 35(4):367, 2021.
Artigo
em Inglês
| ProQuest Central | ID: covidwho-2026938
ABSTRACT
Background:
Anti-SARS-CoV-2 antibody tests are increasingly used for sero-epidemiological purposes to provide a better understanding of the extent of the infection in the community, and to monitor the progression of the COVID-19 epidemic. A sero-prevalence study was conducted to estimate prior infections with SARS-CoV-2 in Addis Ababa.Methods:
A cross-sectional study was conducted from April 23 to 28, 2020 among 301 randomly selected residents of Addis Ababa;sub-city health offices, health facilities and health extension workers were contacted, to obtain a population profile and to conduct the random selection of study participants. Participants were selected, who had not been in direct contact with people who had contracted COVID-19, to maintain consistency among the study population. Interviews on socio demographic and behavioural risk factors, followed by serological tests were performed for SARS-CoV-2 IgM, and IgG antibodies, using the COVID-19 IgG/IgM Rapid Test Cassette. Based on the manufacturer information, the test has a sensitivity of 87·9% and specificity of 100% for lgM;and a sensitivity of 97·2% and specificity of 100% for IgG. A Polymerase chain reaction (RT-PCR) test was also done on combined nasopharyngeal and oropharengeal swabs.Findings:
The unadjusted antibody-based crude SARS-CoV-2 prevalence was 7·6% and the adjusted (weighted average) SARS-CoV-2 prevalence was estimated at 8·8% (95% CI 5·5%-11·6%) for the study population. Higher sero-prevalence were observed for males (9.0%), age below 50 years (8.2%), students and unemployed (15.6%), as well as those with primary education (12.1%), educated above high school (37·9%), non- smokers (78·7%), with no history of regular alcohol (53·8%), no chat (70·8%), and no shisha use (94·7%). According to the findings, a significantly higher number of individuals had been infected in Addis Ababa as compared to what was being detected and reported by the RT-PCR test, which is suggestive of community transmission.
Public Health And Safety; Epidemics; Smoking; Antibodies; Serological tests; Epidemiology; Severe acute respiratory syndrome coronavirus 2; Polymerase chain reaction; COVID-19; Viral diseases; Risk analysis; Health care facilities; Risk taking; Sensitivity; Severe acute respiratory syndrome; Immunoglobulin M; Infections; Sensitivity analysis; Risk factors; Immunoglobulin G; Coronaviruses; Population studies; Disease transmission; Ethiopia; Addis Ababa Ethiopia
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Coleções:
Bases de dados de organismos internacionais
Base de dados:
ProQuest Central
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Revista:
The Ethiopian Journal of Health Development
Ano de publicação:
2021
Tipo de documento:
Artigo
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