Your browser doesn't support javascript.
Possible intraindividual evolution of SARS-CoV-2 in nasopharyngeal and anal swab in an octogenarian: a case report.
Zaini, Jamal; Putra, Andika Chandra; Ridwanuloh, Asep Muhamad; Saniyyah, Zahrah; Haryanto, Budi; Utomo, Ahmad Rusdan Handoyo; Dharmayanthi, Anik Budhi; Prasetyoputri, Anggia; Andriani, Ade; Hariyatun, Hariyatun; Nuryana, Isa; Iryanto, Syam Budi; Saputra, Sugiyono; Wardiana, Andri; Ningrum, Ratih Asmana.
  • Zaini J; MD, PhD, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, 13230, Jakarta Timur, Indonesia.
  • Putra AC; MD, PhD, Faculty of Medicine, Universitas Yarsi, 10510, Jakarta Pusat, Indonesia, Persahabatan National Respiratory Referral Hospital, 13230, Jakarta Timur, Indonesia.
  • Ridwanuloh AM; MSc, National Research and Innovation Agency Republic of Indonesia, Jalan Raya Bogor KM 46 Cibinong, Bogor 16911, Jawa Barat, Indonesia.
  • Saniyyah Z; MD, Faculty of Medicine, Universitas Yarsi, 10510, Jakarta Pusat, Indonesia.
  • Haryanto B; MD, Department of Microbiology, Persahabatan National Respiratory Referral Hospital, 13230, Jakarta Timur, Indonesia.
  • Utomo ARH; PhD, Graduate School of Biomedical Science Master Program, Universitas Yarsi, 10510, Jakarta Pusat, Indonesia And Dharmais Hospital National Cancer Center, 11480, Jakarta, Indonesia.
  • Dharmayanthi AB; PhD, National Research and Innovation Agency Republic of Indonesia, Jalan Raya Bogor KM 46 Cibinong, Bogor 16911, Jawa Barat, Indonesia.
  • Prasetyoputri A; PhD, National Research and Innovation Agency Republic of Indonesia, Jalan Raya Bogor KM 46 Cibinong, Bogor 16911, Jawa Barat, Indonesia.
  • Andriani A; PhD, National Research and Innovation Agency Republic of Indonesia, Jalan Raya Bogor KM 46 Cibinong, Bogor 16911, Jawa Barat, Indonesia.
  • Hariyatun H; MSc, National Research and Innovation Agency Republic of Indonesia, Jalan Raya Bogor KM 46 Cibinong, Bogor 16911, Jawa Barat, Indonesia.
  • Nuryana I; MSc, National Research and Innovation Agency Republic of Indonesia, Jalan Raya Bogor KM 46 Cibinong, Bogor 16911, Jawa Barat, Indonesia.
  • Iryanto SB; MSc, National Research and Innovation Agency Republic of Indonesia, Jalan Raya Bogor KM 46 Cibinong, Bogor 16911, Jawa Barat, Indonesia.
  • Saputra S; PhD, National Research and Innovation Agency Republic of Indonesia, Jalan Raya Bogor KM 46 Cibinong, Bogor 16911, Jawa Barat, Indonesia.
  • Wardiana A; PhD, National Research and Innovation Agency Republic of Indonesia, Jalan Raya Bogor KM 46 Cibinong, Bogor 16911, Jawa Barat, Indonesia.
  • Ningrum RA; PhD, National Research and Innovation Agency Republic of Indonesia, Jalan Raya Bogor KM 46 Cibinong, Bogor 16911, Jawa Barat, Indonesia.
Germs ; 12(2): 298-303, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: covidwho-2033515
ABSTRACT

Introduction:

COVID-19 is an emerging infectious disease that remains to be further investigated. Case report Here, we describe a case of COVID-19 in an octogenarian woman with comorbidities who slowly recovered during hospitalization, but died due to sudden cardiac death after 2 weeks of hospitalization. Her nasopharyngeal and anal swabs returned positive for SARS-CoV-2 by RT-PCR on day 7 of hospitalization. The NGS showed possible intraindividual evolution of virus. The sample from the nasopharyngeal swab yielded a B.1470 variant classified as clade GH. This variant showed mutation in the spike gene D614G; N gene; NS3 gene; NSP2 gene and NSP12 gene. The sample from the anal swab showed similar mutation but with additional point mutation in spike gene S12F and was classified as B.1.465 variant.

Conclusions:

The possibility of the gastrointestinal tract that served as reservoir for virus mutation accumulation should also be considered and the potential impact of viral fecal transmission in the environment should be further investigated.
Palavras-chave

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Relato de caso Tópicos: Variantes Idioma: Inglês Revista: Germs Ano de publicação: 2022 Tipo de documento: Artigo País de afiliação: Germs.2022.1332

Similares

MEDLINE

...
LILACS

LIS


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Relato de caso Tópicos: Variantes Idioma: Inglês Revista: Germs Ano de publicação: 2022 Tipo de documento: Artigo País de afiliação: Germs.2022.1332