Correlation of Coagulation Parameters with Clinical Outcome of Critically Ill Patients with COVID-19 Admitted to an Intensive Care at Rsup Dr. M. Djamil in Indonesia

ABSTRACT

BACKGROUND: COVID-19 is a condition that is characterized by an abnormal coagulation state, which is a reason for severe thrombotic problems. AIM: We aim to determine the correlation of coagulation parameters levels with clinical outcomes of critically ill patients with COVID-19 admitted to intensive care at a national referral hospital in Indonesia. METHOD(S) This retrospective cohort study analyzed 227 patients with a primary diagnosis of COVID-19 on mechanical ventilation who were admitted to the COVID-19 intensive care unit, Dr. M. Djamil from 2020 to 2021 taken in the medical record. Numerical data were analyzed using an independent t-test, while the categorical data were analyzed using the Chi-square test. RESULT(S) One hundred and one patients were >65 years old. The mean +/- SD of INR levels, D-dimer levels, and platelet count on the first and the 5th days were 1.22 +/- 0.77 and 1.36 +/- 1.16;4.624 +/- 3.533 microg/L and 4.334 +/- 3.365 microg/L;and 160.162 +/- 117.203/microl and 234.070 +/- 126.816/microl. There was a significant correlation between age (p = 0.002), INR levels on the 5th day (p = 0.041), platelet count on the 5th day (0.012) with clinical outcomes of patients. CONCLUSION(S) There is a significant increase in the average platelets and INR levels on day 5. There is a significant correlation between INR levels and platelet count on 5th days with clinical outcomes of patients. Copyright © 2022 Dedy Kurnia, Eti Yerizel, Andani Ekaputra, Dwitya Elvira.