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Diverse Presentation of Mucormycosis: A Post COVID Catastrophe - A Case Series
Journal International Medical Sciences Academy ; 35(2):159-166, 2022.
Artigo em Inglês | EMBASE | ID: covidwho-2229284
ABSTRACT
The corona virus disease-19 (COVID-19) produced by SARS-CoV-2 has resulted in a wide spectrum of illness ranging from mild to life-threatening conditions thus enhancing the incidence of opportunistic infections among individuals harbouring comorbidities. Mucormycosis is a dreadful angio-invasive opportunistic infection produced by zygomycetes fungus in an immunocompromised host. The clinical manifestations of mucormycosis include rhino-orbital-cerebral (ROC), pulmonary, cutaneous, gastrointestinal, with ROC accounting for around 40% of cases. Diabetes, neutropenia, iron overload, cancer, and organ transplant are all major culprits. Both Aspergillus and Candida have been identified as the primary fungal pathogens causing co-infection in COVID-19 preyed individuals. The most predominant variety, Rhizopus Oryzae, is responsible for roughly 60% of mucormycosis infections in humans, as well as 90% of the Rhino-orbital-cerebral (ROCM) variant. Mucormycosis is the most widespread ailment in India. Until lately, India was declared to be the world's diabetes capital, with the second-largest number of people suffering from diabetes mellitus (DM). Diabetes has been recognised as the most common predictive marker for mucormycosis which explains the dramatic rise in Mucor cases in India lately particularly during second wave of COVID-19. The inflammatory onslaught caused by COVID 19 has debilitated patients' immune systems, making individuals vulnerable to mucormycosis outbreaks. The possible explanation that Mucorales spores appear to be expediting germination in people with COVID-19 is due to the perfect scenario of oxygen deprivation (hypoxia), hyperglycemia (steroid-induced), acidic form of media (metabolic acidosis, diabetic ketoacidosis), increased iron levels (elevated ferritin), and significantly reduced phagocytic activity of white blood cells (WBC) due to immunosuppression (SARS-CoV-2 or steroid mediated or associated comorbidities). Copyright © 2022 International Medical Sciences Academy. All rights reserved.
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Coleções: Bases de dados de organismos internacionais Base de dados: EMBASE Tipo de estudo: Estudo observacional / Estudo prognóstico Tópicos: Covid persistente / Variantes Idioma: Inglês Revista: Journal International Medical Sciences Academy Ano de publicação: 2022 Tipo de documento: Artigo

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Coleções: Bases de dados de organismos internacionais Base de dados: EMBASE Tipo de estudo: Estudo observacional / Estudo prognóstico Tópicos: Covid persistente / Variantes Idioma: Inglês Revista: Journal International Medical Sciences Academy Ano de publicação: 2022 Tipo de documento: Artigo