Mucormycosis, Covid -19 & Diabetes "THE TROUBLESOME THREESOME"
European Journal of Molecular and Clinical Medicine
; 10(1):3502-3507, 2023.
Artigo
em Inglês
| EMBASE | ID: covidwho-2233354
ABSTRACT
Background:
Covid-19 infection time and again has been causing major morbidities and mortalities. Increased vulnerability of Covid-19 recovered patients was seen towards mucormycosis infection. Mucormycosisis is an aggressive, angioinvasive fungal disease caued by fungi of order Mucorales. This increase in cases may be attributed to a weakened immune system, pre-existing comorbidities such as diabetes, overzealous use of steroids. We conducted a study on 25 cases admitted in mucor ward in a tertiary care setting to highlight this association and focusing on possible causes so that we can be prepared to handle any such catastrophe in future in a better way. Methods andResults:
We did a retrospective study on 25 cases admitted in a tertiary care center catering to large population of Covid -19 patients with varying severity.Covid-19 associated mucormycosis(CAM) was found to be more common in males(76%).Diabetes mellitus was the most common underlying condition(72%).68% patients had received steroids and antibiotics, 28% patients had history of receiving Oxygen. In CAM predominant presentation was rhino-orbital mucormycosis. Unilateral orbit involvement was seen in (88%) cases. Conclusion(s) As severe acute respiratory syndrome coronavirus-2 is highly susceptible to mutations and is causingseries of waves, its association with opportunistic fungal infection is a serious concern. Incidences of mucormycosis were increased in Covid-19 patients due to immune modulation and coexistence of immunosuppressive conditions such as diabetes. Concurrent glucocorticoid therapy further heightens the risk. Early diagnosis and prompt intervention can help improve outcome. Copyright © 2023 Ubiquity Press. All rights reserved.
Covid associated mucormycosis(CAM); Covid-19; diabetes; immunocompromised; Rhino-orbital mucormycosis; adult; article; catering service; clinical article; comorbidity; coronavirus disease 2019; diabetes mellitus; disaster; drug combination; drug therapy; early diagnosis; genetic susceptibility; human; immune system; immunomodulation; incidence; male; mucormycosis; mycosis; nonhuman; retrospective study; Severe acute respiratory syndrome coronavirus 2; tertiary care center; antibiotic agent; glucocorticoid; oxygen
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Coleções:
Bases de dados de organismos internacionais
Base de dados:
EMBASE
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Idioma:
Inglês
Revista:
European Journal of Molecular and Clinical Medicine
Ano de publicação:
2023
Tipo de documento:
Artigo
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