The effect of vitamin C on the risk of mortality in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.
Inflammopharmacology
; 2023 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: covidwho-2298164
ABSTRACT
BACKGROUND AND AIMS:
Vitamin C appears to be a viable treatment option for patients with COVID-19.METHODS:
We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) of vitamin C versus comparative interventions in patients with COVID-19. The outcome of interest was all-cause mortality.RESULTS:
The meta-analysis of eleven trials using a random-effects model revealed significant reduction in the risk of all-cause mortality with the administration of vitamin C among patients with COVID-19 relative to no vitamin C (pooled odds ratio = 0.53; 95% confidence interval 0.30-0.92). Subgroup analysis of studies that included patients with severe COVID-19 also produced findings of significant mortality reduction with the administration of vitamin C relative to no vitamin C (pooled odds ratio = 0.47; 95% confidence interval 0.26-0.84).CONCLUSION:
Overall, evidence from RCTs suggests a survival benefit for vitamin C in patients with severe COVID-19. However, we should await data from large-scale randomized trials to affirm its mortality benefits.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Tipo de estudo:
Estudo experimental
/
Estudo prognóstico
/
Ensaios controlados aleatorizados
/
Revisões
/
Revisão sistemática/Meta-análise
Idioma:
Inglês
Assunto da revista:
Farmacologia
/
Terapia por Medicamentos
Ano de publicação:
2023
Tipo de documento:
Artigo
País de afiliação:
S10787-023-01200-5
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