Variable Levels of Oxytocin During Sepsis: The Role of Oxytocin in Sepsis Pathophysiology.
J Intensive Care Med
; : 8850666231177255, 2023 May 21.
Artigo
em Inglês
| MEDLINE | ID: covidwho-2327179
ABSTRACT
BACKGROUND:
Although the role of oxytocin in the pathophysiology of sepsis is still unknown, rising preclinical evidence suggests that oxytocin is possibly involved. However, no direct clinical studies have measured the levels of oxytocin during sepsis. In this preliminary study, the serum oxytocin levels were evaluated throughout the duration of sepsis.METHOD:
Twenty-two male patients over 18 years of age with a SOFA score of 2 points or more who were admitted to the ICU were included. Patients with a history of neuroendocrine, psychiatric, and neurologic disorders, cancer, an infection caused by COVID-19, shock due to reasons other than sepsis, a history of psychiatric or neurologic medication use, and those who died during the study were excluded. The main endpoint included the measurement of serum oxytocin levels using radioimmunoassay at 6, 24, and 48â h of the ICU admission.RESULTS:
Mean serum oxytocin level was higher at 6â h of ICU admission (41.27 ± 13.14â ng/L) than after 24 and 48â h of ICU admission (22.63 ± 5.75 and 20.97 ± 7.61â ng/L respectively) (P-value < .001).CONCLUSION:
Our study, while reporting increased serum oxytocin levels in the initial phase of sepsis and decline afterward, supports the possible contribution of oxytocin in the pathophysiology of sepsis. Given that oxytocin seems to modulate the innate immune system, future investigations are necessary to assess the potential role of oxytocin in the pathophysiology of sepsis.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Tipo de estudo:
Estudo experimental
/
Estudo prognóstico
Idioma:
Inglês
Revista:
J Intensive Care Med
Assunto da revista:
Terapia Intensiva
Ano de publicação:
2023
Tipo de documento:
Artigo
País de afiliação:
08850666231177255
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