Olfactory and Gustatory Dysfunction as an Early Identifier of COVID-19 in Adults and Children: An International Multicenter Study.
Otolaryngol Head Neck Surg
; 163(4): 714-721, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: covidwho-999415
Preprint
Este artigo de periódico científico é provavelmente baseado em um preprint previamente disponível, por meio do reconhecimento de similaridade realizado por uma máquina. A confirmação humana ainda está pendente.
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Este artigo de periódico científico é provavelmente baseado em um preprint previamente disponível, por meio do reconhecimento de similaridade realizado por uma máquina. A confirmação humana ainda está pendente.
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ABSTRACT
OBJECTIVE:
To evaluate the prevalence and characteristics of olfactory or gustatory dysfunction in coronavirus disease 2019 (COVID-19) patients. STUDYDESIGN:
Multicenter case series.SETTING:
Five tertiary care hospitals (3 in China, 1 in France, 1 in Germany). SUBJECTS ANDMETHODS:
In total, 394 polymerase chain reaction (PCR)-confirmed COVID-19-positive patients were screened, and those with olfactory or gustatory dysfunction were included. Data including demographics, COVID-19 severity, patient outcome, and the incidence and degree of olfactory and/or gustatory dysfunction were collected and analyzed. The Questionnaire of Olfactory Disorders (QOD) and visual analog scale (VAS) were used to quantify olfactory and gustatory dysfunction, respectively. All subjects at 1 hospital (Shanghai) without subjective olfactory complaints underwent objective testing.RESULTS:
Of 394 screened subjects, 161 (41%) reported olfactory and/or gustatory dysfunction and were included. Incidence of olfactory and/or gustatory disorders in Chinese (n = 239), German (n = 39), and French (n = 116) cohorts was 32%, 69%, and 49%, respectively. The median age of included subjects was 39 years, 92 of 161 (57%) were male, and 10 of 161 (6%) were children. Of included subjects, 10% had only olfactory or gustatory symptoms, and 19% had olfactory and/or gustatory complaints prior to any other COVID-19 symptom. Of subjects with objective olfactory testing, 10 of 90 demonstrated abnormal chemosensory function despite reporting normal subjective olfaction. Forty-three percent (44/102) of subjects with follow-up showed symptomatic improvement in olfaction or gustation.CONCLUSIONS:
Olfactory and/or gustatory disorders may represent early or isolated symptoms of severe acute respiratory syndrome coronavirus 2 infection. They may serve as a useful additional screening criterion, particularly for the identification of patients in the early stages of infection.Palavras-chave
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
/
Olfato
/
Distúrbios do Paladar
/
Infecções por Coronavirus
/
Diagnóstico Precoce
/
Betacoronavirus
/
Transtornos do Olfato
Tipo de estudo:
Estudo de coorte
/
Estudo diagnóstico
/
Estudo experimental
/
Estudo observacional
/
Estudo prognóstico
Tópicos:
Covid persistente
Limite:
Adolescente
/
Adulto
/
Criança
/
Feminino
/
Humanos
/
Masculino
/
Jovem adulto
País/Região como assunto:
Ásia
/
Europa
Idioma:
Inglês
Revista:
Otolaryngol Head Neck Surg
Assunto da revista:
Otorrinolaringologia
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
0194599820934376
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