Finding Metabolomic Signatures in Pregnancy that Predict Breast Cancer: 60-Year Prospective Study in the Child Health and Development Studies Pregnancy Cohort

ABSTRACT

We propose to study 2nd and 3rd trimester archival serum samples of women in the Child Health and Development Studies (CHDS) pregnancy cohort who subsequently developed breast cancer, compared to 2nd and 3rd trimester archival serum samples from women who did not develop breast cancer, to identify predictive gestational biomarkers which could lead to new approaches to prevent breast cancer. For this, we will apply powerful high-resolution metabolomics (HRM) with advanced computational tools to identify chemicals and biochemical metabolic networks in pregnancy which are linked to subsequent breast cancer occurrence. There were minor delays caused by staff and offices transitioning to remote work due to the COVID-19 pandemic. We still accomplished all major tasks specified in the first year (obtaining all human subjects approvals, sample selection, preparation and order of archived pregnancy serum for delivery to Site 2).