Analysis of pathological changes in the epithelium in COVID-19 patient airways.

Yin, Wenguang; Cao, Weitao; Zhou, Guangde; Wang, Lifei; Sun, Jing; Zhu, Airu; Wang, Zhongfang; Zhou, Yumin; Liu, Xiaoqing; Li, Yimin; Zhong, Nanshan; Zhao, Jincun; Liu, Lei; Ran, Pixin

Yin, Wenguang; Cao, Weitao; Zhou, Guangde; Wang, Lifei; Sun, Jing; Zhu, Airu; Wang, Zhongfang; Zhou, Yumin; Liu, Xiaoqing; Li, Yimin; Zhong, Nanshan; Zhao, Jincun; Liu, Lei; Ran, Pixin.

Yin W; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Cao W; These authors contributed equally.
Zhou G; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wang L; These authors contributed equally.
Sun J; Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
Zhu A; These authors contributed equally.
Wang Z; Dept of Radiology, National Clinical Research Center for Infectious Disease, Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
Zhou Y; These authors contributed equally.
Liu X; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Li Y; These authors contributed equally.
Zhong N; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhao J; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Liu L; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Ran P; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

ERJ Open Res ; 7(2)2021 Apr.

Статья в английский | MEDLINE | ID: covidwho-1172825

ABSTRACT

ABSTRACT

Severe COVID-19 patient airways plugged by MUC5AC-containing mucus exhibit hyperplasia of goblet cells, and hypoplasia of multiciliated cells and club cells, as well as significantly reduced CC16 and MUC5B levels, and increased IL-13 levels https//bit.ly/2M2NcdO.

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Язык: английский Год: 2021 Тип: Статья Аффилированная страна: 23120541.00690-2020

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