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Is Hydroxychloroquine with Azithromycin a Good Combination in COVID-19 Compared to Hydroxychloroquine Alone from Cardiac Perspective? A Systematic Review and Meta-Analysis.
Budhathoki, Pravash; Shrestha, Dhan Bahadur; Khadka, Sitaram; Rawal, Era.
  • Budhathoki P; Department of Emergency Medicine, Dr Iwamura Memorial Hospital, Bhaktapur-44800, Nepal.
  • Shrestha DB; Department of Emergency Medicine, Mangalbare Hospital, Morang-56600, Nepal.
  • Khadka S; Department of Pharmacy, Shree Birendra Hospital; Nepalese Army Institute of Health Sciences, Kathmandu-44600, Nepal.
  • Rawal E; Department of Emergency Medicine, Kathmandu Medical College, Kathmandu-44600, Nepal.
J Nepal Health Res Counc ; 19(1): 1-9, 2021 Apr 23.
Статья в английский | MEDLINE | ID: covidwho-1209433
ABSTRACT

BACKGROUND:

The global spread of COVID-19 and the lack of definite treatment have caused an alarming crisis in the world. We aimed to evaluate the outcome and potential harmful cardiac effects of hydroxychloroquine and azithromycin compared to hydroxychloroquine alone for COVID-19 treatment.

METHODS:

PubMed, Medline, Google Scholar, Cochrane Library, clinicaltrials.gov, and World Health Organization clinical trial registry were searched using appropriate keywords and identified six studies using PRISMA guidelines. The quantitative synthesis was performed using fixed or random effects for the pooling of studies based on heterogeneities.

RESULTS:

The risk of mortality (RR=1.16; CI 0.92-1.46) and adverse cardiac events (OR=1.06; CI 0.82-1.37) demonstrated a small increment though of no significance. There were no increased odds of mechanical ventilation (OR=0.84; CI 0.33-2.15) and significant QTc prolongation (OR=0.84, CI 0.59-1.21). Neither the critical QTc threshold (OR=1.92, CI 0.81-4.56) nor absolute ?QTc ?60ms (OR=1.95, CI0.55-6.96) increased to the level of statistical significance among hydroxychloroquine and azithromycin arm compared to hydroxychloroquine alone, but the slightly increased odds need to be considered in clinical practice.

CONCLUSIONS:

The combination of hydroxychloroquine and azithromycin leads to small increased odds of mortality and cardiac events compared to hydroxychloroquine alone. The use of hydroxychloroquine and azithromycin led to increased odds of QT prolongation, although not statistically significant.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Pneumonia, Viral / Cardiovascular Diseases / Azithromycin / COVID-19 Drug Treatment / Hydroxychloroquine Тип исследования: Экспериментальные исследования / Прогностическое исследование / Рандомизированные контролируемые испытания / Отзывы / Систематический обзор/метаанализ Пределы темы: Люди Язык: английский Журнал: J Nepal Health Res Counc Тематика журнала: Исследования услуг здравоохранения Год: 2021 Тип: Статья Аффилированная страна: Jnhrc.v19i1.3270

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Pneumonia, Viral / Cardiovascular Diseases / Azithromycin / COVID-19 Drug Treatment / Hydroxychloroquine Тип исследования: Экспериментальные исследования / Прогностическое исследование / Рандомизированные контролируемые испытания / Отзывы / Систематический обзор/метаанализ Пределы темы: Люди Язык: английский Журнал: J Nepal Health Res Counc Тематика журнала: Исследования услуг здравоохранения Год: 2021 Тип: Статья Аффилированная страна: Jnhrc.v19i1.3270