Your browser doesn't support javascript.
Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 Spike protein.
Gasparello, Jessica; D'Aversa, Elisabetta; Papi, Chiara; Gambari, Laura; Grigolo, Brunella; Borgatti, Monica; Finotti, Alessia; Gambari, Roberto.
  • Gasparello J; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
  • D'Aversa E; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
  • Papi C; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
  • Gambari L; Laboratorio RAMSES, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Grigolo B; Laboratorio RAMSES, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Borgatti M; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
  • Finotti A; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy; Research Center for Innovative Therapies of Cystic Fibrosis, University of Ferrara, Italy. Electronic address: alessia.finotti@unife.it.
  • Gambari R; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy; Italian Consortium for Biotechnologies (C.I.B.); Research Center for Innovative Therapies of Cystic Fibrosis, University of Ferrara, Italy. Electronic address: gam@unife.it.
Phytomedicine ; 87: 153583, 2021 Jul.
Статья в английский | MEDLINE | ID: covidwho-1213465
ABSTRACT

BACKGROUND:

A key clinical feature of COVID-19 is a deep inflammatory state known as "cytokine storm" and characterized by high expression of several cytokines, chemokines and growth factors, including IL-6 and IL-8. A direct consequence of this inflammatory state in the lungs is the Acute Respiratory Distress Syndrome (ARDS), frequently observed in severe COVID-19 patients. The "cytokine storm" is associated with severe forms of COVID-19 and poor prognosis for COVID-19 patients. Sulforaphane (SFN), one of the main components of Brassica oleraceae L. (Brassicaceae or Cruciferae), is known to possess anti-inflammatory effects in tissues from several organs, among which joints, kidneys and lungs.

PURPOSE:

The objective of the present study was to determine whether SFN is able to inhibit IL-6 and IL-8, two key molecules involved in the COVID-19 "cytokine storm".

METHODS:

The effects of SFN were studied in vitro on bronchial epithelial IB3-1 cells exposed to the SARS-CoV-2 Spike protein (S-protein). The anti-inflammatory activity of SFN on IL-6 and IL-8 expression has been evaluated by RT-qPCR and Bio-Plex analysis.

RESULTS:

In our study SFN inhibits, in cultured IB3-1 bronchial cells, the gene expression of IL-6 and IL-8 induced by the S-protein of SARS-CoV-2. This represents the proof-of-principle that SFN may modulate the release of some key proteins of the COVID-19 "cytokine storm".

CONCLUSION:

The control of the cytokine storm is one of the major issues in the management of COVID-19 patients. Our study suggests that SFN can be employed in protocols useful to control hyperinflammatory state associated with SARS-CoV-2 infection.
Тема - темы
ключевые слова

Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Sulfoxides / Bronchi / Interleukin-8 / Interleukin-6 / Isothiocyanates / Spike Glycoprotein, Coronavirus Тип исследования: Экспериментальные исследования / Прогностическое исследование Пределы темы: Люди Язык: английский Журнал: Phytomedicine Тематика журнала: Комплементарные методы лечения Год: 2021 Тип: Статья Аффилированная страна: J.phymed.2021.153583

Документы, близкие по теме

MEDLINE

...
LILACS

LIS


Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Sulfoxides / Bronchi / Interleukin-8 / Interleukin-6 / Isothiocyanates / Spike Glycoprotein, Coronavirus Тип исследования: Экспериментальные исследования / Прогностическое исследование Пределы темы: Люди Язык: английский Журнал: Phytomedicine Тематика журнала: Комплементарные методы лечения Год: 2021 Тип: Статья Аффилированная страна: J.phymed.2021.153583