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SARS-CoV-2 Induces Lymphocytopenia by Promoting Inflammation and Decimates Secondary Lymphoid Organs.
Xiang, Qun; Feng, Zeqing; Diao, Bo; Tu, Chao; Qiao, Qinghua; Yang, Han; Zhang, Yi; Wang, Gang; Wang, Huiming; Wang, Chenhui; Liu, Liang; Wang, Changsong; Liu, Longding; Chen, Rong; Wu, Yuzhang; Chen, Yongwen.
  • Xiang Q; Institute of Immunology, PLA, Third Military Medical University, Chongqing, China.
  • Feng Z; Institute of Immunology, PLA, Third Military Medical University, Chongqing, China.
  • Diao B; Department of Medical Laboratory Center, General Hospital of Central Theater Command, Wuhan, China.
  • Tu C; Department of Pathology, Jinyintan Hospital, Wuhan, China.
  • Qiao Q; Pingdingshan Medical District, The 989th Hospital of the PLA Joint Logistic Support Force, Pingdingshan, China.
  • Yang H; Institute of Immunology, PLA, Third Military Medical University, Chongqing, China.
  • Zhang Y; Institute of Immunology, PLA, Third Military Medical University, Chongqing, China.
  • Wang G; Department of Medical Laboratory Center, General Hospital of Central Theater Command, Wuhan, China.
  • Wang H; Department of Nephrology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Wang C; Institute of Immunology, PLA, Third Military Medical University, Chongqing, China.
  • Liu L; Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wang C; Department of Pathology, 989th Hospital of PLA, Luoyang, China.
  • Liu L; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming, China.
  • Chen R; Department of Pathology, Jinyintan Hospital, Wuhan, China.
  • Wu Y; Institute of Immunology, PLA, Third Military Medical University, Chongqing, China.
  • Chen Y; Institute of Immunology, PLA, Third Military Medical University, Chongqing, China.
Front Immunol ; 12: 661052, 2021.
Статья в английский | MEDLINE | ID: covidwho-1229177
ABSTRACT
While lymphocytopenia is a common characteristic of coronavirus disease 2019 (COVID-19), the mechanisms responsible for this lymphocyte depletion are unclear. Here, we retrospectively reviewed the clinical and immunological data from 18 fatal COVID-19 cases, results showed that these patients had severe lymphocytopenia, together with high serum levels of inflammatory cytokines (IL-6, IL-8 and IL-10), and elevation of many other mediators in routine laboratory tests, including C-reactive protein, lactate dehydrogenase, α-hydroxybutyrate dehydrogenase and natriuretic peptide type B. The spleens and hilar lymph nodes (LNs) from six additional COVID-19 patients with post-mortem examinations were also collected, histopathologic detection showed that both organs manifested severe tissue damage and lymphocyte apoptosis in these six cases. In situ hybridization assays illustrated that SARS-CoV-2 viral RNA accumulates in these tissues, and transmission electronic microscopy confirmed that coronavirus-like particles were visible in the LNs. SARS-CoV-2 Spike and Nucleocapsid protein (NP) accumulated in the spleens and LNs, and the NP antigen restricted in angiotensin-converting enzyme 2 (ACE2) positive macrophages and dendritic cells (DCs). Furthermore, SARS-CoV-2 triggered the transcription of Il6, Il8 and Il1b genes in infected primary macrophages and DCs in vitro, and SARS-CoV-2-NP+ macrophages and DCs also manifested high levels of IL-6 and IL-1ß, which might directly decimate human spleens and LNs and subsequently lead to lymphocytopenia in vivo. Collectively, these results demonstrated that SARS-CoV-2 induced lymphocytopenia by promoting systemic inflammation and direct neutralization in human spleen and LNs.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Spleen / SARS-CoV-2 / COVID-19 / Lymph Nodes / Lymphopenia Тип исследования: Наблюдательное исследование / Прогностическое исследование Темы: Длинный Ковид Пределы темы: Женщины / Люди / Middle aged Язык: английский Журнал: Front Immunol Год: 2021 Тип: Статья Аффилированная страна: Fimmu.2021.661052

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Spleen / SARS-CoV-2 / COVID-19 / Lymph Nodes / Lymphopenia Тип исследования: Наблюдательное исследование / Прогностическое исследование Темы: Длинный Ковид Пределы темы: Женщины / Люди / Middle aged Язык: английский Журнал: Front Immunol Год: 2021 Тип: Статья Аффилированная страна: Fimmu.2021.661052