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Mesenchymal Stromal Cell Secretome for Post-COVID-19 Pulmonary Fibrosis: A New Therapy to Treat the Long-Term Lung Sequelae?
Bari, Elia; Ferrarotti, Ilaria; Saracino, Laura; Perteghella, Sara; Torre, Maria Luisa; Richeldi, Luca; Corsico, Angelo Guido.
  • Bari E; Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
  • Ferrarotti I; Center for Diagnosis of Inherited Alpha1-Antitrypsin Deficiency, Department of Internal Medicine and Therapeutics, Pneumology Unit IRCCS San Matteo Hospital Foundation, University of Pavia, 27100 Pavia, Italy.
  • Saracino L; Pneumology Unit IRCCS San Matteo Hospital Foundation, 27100 Pavia, Italy.
  • Perteghella S; Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
  • Torre ML; PharmaExceed S.r.l., 27100 Pavia, Italy.
  • Richeldi L; Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
  • Corsico AG; PharmaExceed S.r.l., 27100 Pavia, Italy.
Cells ; 10(5)2021 05 14.
Статья в английский | MEDLINE | ID: covidwho-1234672
ABSTRACT
To date, more than 100 million people worldwide have recovered from COVID-19. Unfortunately, although the virus is eradicated in such patients, fibrotic irreversible interstitial lung disease (pulmonary fibrosis, PF) is clinically evident. Given the vast numbers of individuals affected, it is urgent to design a strategy to prevent a second wave of late mortality associated with COVID-19 PF as a long-term consequence of such a devastating pandemic. Available antifibrotic therapies, namely nintedanib and pirfenidone, might have a role in attenuating profibrotic pathways in SARS-CoV-2 infection but are not economically sustainable by national health systems and have critical adverse effects. It is our opinion that the mesenchymal stem cell secretome could offer a new therapeutic approach in treating COVID-19 fibrotic lungs through its anti-inflammatory and antifibrotic factors.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Pulmonary Fibrosis / Biological Factors / Mesenchymal Stem Cells / COVID-19 Тип исследования: Прогностическое исследование Темы: Длинный Ковид Пределы темы: Люди Язык: английский Год: 2021 Тип: Статья Аффилированная страна: Cells10051203

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Pulmonary Fibrosis / Biological Factors / Mesenchymal Stem Cells / COVID-19 Тип исследования: Прогностическое исследование Темы: Длинный Ковид Пределы темы: Люди Язык: английский Год: 2021 Тип: Статья Аффилированная страна: Cells10051203