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Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine.
Beharier, Ofer; Plitman Mayo, Romina; Raz, Tal; Nahum Sacks, Kira; Schreiber, Letizia; Suissa-Cohen, Yael; Chen, Rony; Gomez-Tolub, Rachel; Hadar, Eran; Gabbay-Benziv, Rinat; Jaffe Moshkovich, Yuval; Biron-Shental, Tal; Shechter-Maor, Gil; Farladansky-Gershnabel, Sivan; Yitzhak Sela, Hen; Benyamini-Raischer, Hedi; Sela, Nitzan D; Goldman-Wohl, Debra; Shulman, Ziv; Many, Ariel; Barr, Haim; Yagel, Simcha; Neeman, Michal; Kovo, Michal.
  • Beharier O; Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
  • Plitman Mayo R; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
  • Raz T; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
  • Nahum Sacks K; Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food & Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
  • Schreiber L; Department Obstetrics and Gynecology, Wolfson Medical Center, Holon; affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Suissa-Cohen Y; Department of Pathology, Wolfson Medical Center, Holon; affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Chen R; Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
  • Gomez-Tolub R; Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva; affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel.
  • Hadar E; Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva; affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel.
  • Gabbay-Benziv R; Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva; affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel.
  • Jaffe Moshkovich Y; The Hillel Yaffe Medical Center, Hadera, Israel; affiliated to the Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
  • Biron-Shental T; The Hillel Yaffe Medical Center, Hadera, Israel; affiliated to the Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
  • Shechter-Maor G; Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel, affiliated to Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Farladansky-Gershnabel S; Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel, affiliated to Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Yitzhak Sela H; Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel, affiliated to Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Benyamini-Raischer H; Department of Obstetrics and Gynecology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Israel.
  • Sela ND; Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel affiliated with Rappaport Faculty of Medicine, Technion, Haifa, Israel.
  • Goldman-Wohl D; Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel affiliated with Rappaport Faculty of Medicine, Technion, Haifa, Israel.
  • Shulman Z; Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
  • Many A; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
  • Barr H; Lis Hospital for Women, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Yagel S; The Nancy and Stephen Grand Israel National Center for Personalized Medicine (G-INCPM), Weizmann Institute of Science, Rehovot, Israel.
  • Neeman M; Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
  • Kovo M; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
J Clin Invest ; 131(13)2021 07 01.
Статья в английский | MEDLINE | ID: covidwho-1236496
ABSTRACT
BACKGROUNDThe significant risks posed to mothers and fetuses by COVID-19 in pregnancy have sparked a worldwide debate surrounding the pros and cons of antenatal SARS-CoV-2 inoculation, as we lack sufficient evidence regarding vaccine effectiveness in pregnant women and their offspring. We aimed to provide substantial evidence for the effect of the BNT162b2 mRNA vaccine versus native infection on maternal humoral, as well as transplacentally acquired fetal immune response, potentially providing newborn protection.METHODSA multicenter study where parturients presenting for delivery were recruited at 8 medical centers across Israel and assigned to 3 study groups vaccinated (n = 86); PCR-confirmed SARS-CoV-2 infected during pregnancy (n = 65), and unvaccinated noninfected controls (n = 62). Maternal and fetal blood samples were collected from parturients prior to delivery and from the umbilical cord following delivery, respectively. Sera IgG and IgM titers were measured using the Milliplex MAP SARS-CoV-2 Antigen Panel (for S1, S2, RBD, and N).RESULTSThe BNT162b2 mRNA vaccine elicits strong maternal humoral IgG response (anti-S and RBD) that crosses the placenta barrier and approaches maternal titers in the fetus within 15 days following the first dose. Maternal to neonatal anti-COVID-19 antibodies ratio did not differ when comparing sensitization (vaccine vs. infection). IgG transfer ratio at birth was significantly lower for third-trimester as compared with second trimester infection. Lastly, fetal IgM response was detected in 5 neonates, all in the infected group.CONCLUSIONAntenatal BNT162b2 mRNA vaccination induces a robust maternal humoral response that effectively transfers to the fetus, supporting the role of vaccination during pregnancy.FUNDINGIsrael Science Foundation and the Weizmann Institute Fondazione Henry Krenter.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Maternal-Fetal Exchange / Antibodies, Viral Тип исследования: Когортное исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Темы: Вакцина Пределы темы: Взрослые / Женщины / Люди / Мужчины / Новорожденные / Беременность / Молодой взрослый Язык: английский Год: 2021 Тип: Статья Аффилированная страна: Jci150319

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Maternal-Fetal Exchange / Antibodies, Viral Тип исследования: Когортное исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Темы: Вакцина Пределы темы: Взрослые / Женщины / Люди / Мужчины / Новорожденные / Беременность / Молодой взрослый Язык: английский Год: 2021 Тип: Статья Аффилированная страна: Jci150319