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Profile of Circulatory Cytokines and Chemokines in Human Coronaviruses: A Systematic Review and Meta-Analysis.
Zawawi, Ayat; Naser, Abdallah Y; Alwafi, Hassan; Minshawi, Faisal.
  • Zawawi A; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Naser AY; Vaccines and Immunotherapy Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Alwafi H; Department of Applied Pharmaceutical Sciences and Clinical Pharmacy, Faculty of Pharmacy, Isra University, Amman, Jordan.
  • Minshawi F; Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Front Immunol ; 12: 666223, 2021.
Статья в английский | MEDLINE | ID: covidwho-1247864
ABSTRACT

BACKGROUND:

SARS, MERS, and COVID-19 share similar characteristics. For instance, the genetic homology of SARS-CoV-2 compared to SARS-CoV and MERS-CoV is 80% and 50%, respectively, which may cause similar clinical features. Moreover, uncontrolled release of proinflammatory mediators (also called a cytokine storm) by activated immune cells in SARS, MERS, and COVID-19 patients leads to severe phenotype development.

AIM:

This systematic review and meta-analysis aimed to evaluate the inflammatory cytokine profile associated with three strains of severe human coronavirus diseases (MERS-CoV, SARS-CoV, and SARS-CoV-2).

METHOD:

The PubMed, Embase, and Cochrane Library databases were searched for studies published until July 2020. Randomized and observational studies reporting the inflammatory cytokines associated with severe and non-severe human coronavirus diseases, including MERS-CoV, SARS-CoV, and SARS-CoV-2, were included. Two reviewers independently screened articles, extracted data, and assessed the quality of the included studies. Meta-analysis was performed using a random-effects model with a 95% confidence interval to estimate the pooled mean of inflammatory biomarkers.

RESULTS:

A high level of circulating IL-6 could be associated with the severity of infection of the three coronavirus strains. TNF, IL-10, and IL-8 are associated with the severity of COVID-19. Increased circulating levels of CXCL10/IP10 and CCL2/MCP-1 might also be related to the severity of MERS.

CONCLUSION:

This study suggests that the immune response and immunopathology in the three severe human coronavirus strains are somewhat similar. The findings highlight that nearly all studies reporting severe cases of SARS, MERS, and COVID-19 have been associated with elevated levels of IL-6. This could be used as a potential therapeutic target to improve patients' outcomes in severe cases. SYSTEMATIC REVIEW REGISTRATION PROSPERO registration 94 number CRD42020209931.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Coronavirus Infections / Coronavirus / Cytokine Release Syndrome / Inflammation Тип исследования: Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания / Отзывы / Систематический обзор/метаанализ Пределы темы: Животные / Люди Язык: английский Журнал: Front Immunol Год: 2021 Тип: Статья Аффилированная страна: Fimmu.2021.666223

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Coronavirus Infections / Coronavirus / Cytokine Release Syndrome / Inflammation Тип исследования: Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания / Отзывы / Систематический обзор/метаанализ Пределы темы: Животные / Люди Язык: английский Журнал: Front Immunol Год: 2021 Тип: Статья Аффилированная страна: Fimmu.2021.666223