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Type 1 inflammatory endotype relates to low compliance, lung fibrosis, and severe complications in COVID-19.
Hasegawa, Takehiro; Nakagawa, Atsushi; Suzuki, Kohjin; Yamashita, Kazuto; Yamashita, Saya; Iwanaga, Niina; Tamada, Eiya; Noda, Kenta; Tomii, Keisuke.
  • Hasegawa T; Sysmex R&D Centre Europe GmbH, Research and Development Division, Falkenried 88, 20251 Hamburg, Germany. Electronic address: Hasegawa.Takehiro@sysmex-rdce.com.
  • Nakagawa A; Kobe City Medical Centre General Hospital, 2-1-1, Minamimachi, Minatojima, Chuo Ward, Kobe, Japan.
  • Suzuki K; Sysmex System Technology Laboratories, 4-4-4, Takatsuka-dai, Nish Ward, Kobe, Japan.
  • Yamashita K; Sysmex Central Research Laboratories, 4-4-4, Takatsuka-dai, Nish Ward, Kobe, Japan.
  • Yamashita S; Sysmex Business Incubation Department, 4-4-4, Takatsuka-dai, Nish Ward, Kobe, Japan.
  • Iwanaga N; Sysmex Central Research Laboratories, 4-4-4, Takatsuka-dai, Nish Ward, Kobe, Japan.
  • Tamada E; Sysmex Central Research Laboratories, 4-4-4, Takatsuka-dai, Nish Ward, Kobe, Japan.
  • Noda K; Sysmex Central Research Laboratories, 4-4-4, Takatsuka-dai, Nish Ward, Kobe, Japan.
  • Tomii K; Kobe City Medical Centre General Hospital, 2-1-1, Minamimachi, Minatojima, Chuo Ward, Kobe, Japan.
Cytokine ; 148: 155618, 2021 12.
Статья в английский | MEDLINE | ID: covidwho-1260707
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19) is an acute respiratory disease; approximately 5% of patients developing severe COVID-19. It is known that cytokine release is associated with disease severity, but the relationship between the different clinical phenotypes and inflammatory endotypes is not well understood.

OBJECTIVE:

This study investigated the association between inflammatory biomarker-based endotypes and severe COVID-19 phenotypes.

METHODS:

Interleukin (IL) -6, C-reactive protein (CRP), C-X-C motif chemokine (CXCL) 9, IL-18, C-C motif chemokine (CCL) 3, CCL17, IL-10, and vascular endothelial growth factor (VEGF) were measured in 57 COVID-19 patients, and their association with clinical characteristics was examined using a cluster analysis.

RESULTS:

Significantly higher blood levels of the eight inflammatory markers were noted in patients who developed acute respiratory distress syndrome (ARDS) than in those who did not develop ARDS (non-ARDS). Using a cluster analysis, the patient groups were classified into four clusters, of which two had patients with high IL-6 and CRP levels. In the cluster with high levels of Type 1 (T1) inflammatory markers such as CXCL9 and IL-18, 85% of the patients had ARDS, 65% of the patients developed acute kidney injury (AKI), and 78% of the patients developed pulmonary fibrosis.

CONCLUSIONS:

In the cluster with high levels of T1 inflammatory markers, the patients frequently suffered from tissue damage, manifested as ARDS and AKI. Our findings identified distinct T1 inflammatory endotypes of COVID-19 and suggest the importance of controlling inflammation by monitoring T1 biomarkers and treating accordingly to limit the severity of the disease.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Pulmonary Fibrosis / COVID-19 / Inflammation Тип исследования: Экспериментальные исследования / Прогностическое исследование / Рандомизированные контролируемые испытания Темы: Длинный Ковид Пределы темы: Пожилые / Женщины / Люди / Мужчины / Middle aged Язык: английский Журнал: Cytokine Тематика журнала: Аллергология и иммунология Год: 2021 Тип: Статья

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Pulmonary Fibrosis / COVID-19 / Inflammation Тип исследования: Экспериментальные исследования / Прогностическое исследование / Рандомизированные контролируемые испытания Темы: Длинный Ковид Пределы темы: Пожилые / Женщины / Люди / Мужчины / Middle aged Язык: английский Журнал: Cytokine Тематика журнала: Аллергология и иммунология Год: 2021 Тип: Статья