A Bayesian Model to Predict COVID-19 Severity in Children.
Pediatr Infect Dis J
; 40(8): e287-e293, 2021 08 01.
Статья
в английский
| MEDLINE | ID: covidwho-1305449
ABSTRACT
BACKGROUND:
We aimed to identify risk factors causing critical disease in hospitalized children with COVID-19 and to build a predictive model to anticipate the probability of need for critical care.METHODS:
We conducted a multicenter, prospective study of children with SARS-CoV-2 infection in 52 Spanish hospitals. The primary outcome was the need for critical care. We used a multivariable Bayesian model to estimate the probability of needing critical care.RESULTS:
The study enrolled 350 children from March 12, 2020, to July 1, 2020 292 (83.4%) and 214 (73.7%) were considered to have relevant COVID-19, of whom 24.2% required critical care. Four major clinical syndromes of decreasing severity were identified multi-inflammatory syndrome (MIS-C) (17.3%), bronchopulmonary (51.4%), gastrointestinal (11.6%), and mild syndrome (19.6%). Main risk factors were high C-reactive protein and creatinine concentration, lymphopenia, low platelets, anemia, tachycardia, age, neutrophilia, leukocytosis, and low oxygen saturation. These risk factors increased the risk of critical disease depending on the syndrome the more severe the syndrome, the more risk the factors conferred. Based on our findings, we developed an online risk prediction tool (https//rserver.h12o.es/pediatria/EPICOAPP/, username user, password 0000).CONCLUSIONS:
Risk factors for severe COVID-19 include inflammation, cytopenia, age, comorbidities, and organ dysfunction. The more severe the syndrome, the more the risk factor increases the risk of critical illness. Risk of severe disease can be predicted with a Bayesian model.
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Systemic Inflammatory Response Syndrome
/
COVID-19
Тип исследования:
Когортное исследование
/
Диагностическое исследование
/
Наблюдательное исследование
/
Прогностическое исследование
Пределы темы:
Подростки
/
Дети
/
Детский дошкольный
/
Женщины
/
Люди
/
Грудные дети
/
Мужчины
/
Новорожденные
Язык:
английский
Журнал:
Pediatr Infect Dis J
Тематика журнала:
Инфекционные болезни
/
Педиатрия
Год:
2021
Тип:
Статья
Аффилированная страна:
INF.0000000000003204
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