Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition.
Carbohydr Polym
; 273: 118567, 2021 Dec 01.
Статья
в английский
| MEDLINE | ID: covidwho-1363900
ABSTRACT
Diffuse alveolar injury and pulmonary fibrosis (PF) are the main causes of death of Covid-19 cases. In this study a low molecular weight fucoidan (LMWF) with unique structural was obtained from Laminaria japonica, and its anti- PF and anti-epithelial-mesenchymal transition (EMT) bioactivity were investigated both in vivo and in vitro. After LWMF treatment the fibrosis and inflammatory factors stimulated by Bleomycin (BLM) were in lung tissue. Immunohistochemical and Western-blot results found the expression of COL2A1, ß-catenin, TGF-ß, TNF-α and IL-6 were declined in mice lung tissue. Besides, the phosphorylation of PI3K and Akt were inhibited by LMWF. In addition, the progression of EMT induced by TGF-ß1 was inhibited by LMWF through down-regulated both TGF-ß/Smad and PI3K/AKT signaling pathways. These data indicate that unique LMWF can protect the lung from fibrosis by weakening the process of inflammation and EMT, and it is a promising therapeutic option for the treatment of PF.
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Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Polysaccharides
/
Pulmonary Fibrosis
/
Epithelial-Mesenchymal Transition
/
SARS-CoV-2
/
COVID-19
Тип исследования:
Прогностическое исследование
Темы:
Длинный Ковид
Пределы темы:
Животные
/
Люди
/
Мужчины
Язык:
английский
Журнал:
Carbohydr Polym
Год:
2021
Тип:
Статья
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