Comparison of standard prophylactic and preemptive therapeutic low molecular weight heparin treatments in hospitalized patients with COVID-19.
Bratisl Lek Listy
; 122(9): 626-630, 2021.
Статья
в английский
| MEDLINE | ID: covidwho-1380028
ABSTRACT
NTRODUCTION Anticoagulant treatment approach in patients with COVID-19 is not well studied and not standardized. We aimed to compare the effects of standard prophylactic and pre-emptive therapeutic Low-Molecular-weight Heparin (LMWH) treatment approaches on mortality in patients with COVID-19. PATIENTS AND METHODS:
This retrospective and single-centre study includes patients aged ≥ 18 years, who were diagnosed with COVID-19 and treated with LMWH during the hospital stay. Therapeutic dose of LMWH was defined as 1 mg/kg subcutaneously twice daily and prophylactic dose of LMWH was defined as 40 mg subcutaneously once daily.RESULTS:
Among the 336 patients diagnosed with COVID-19 pneumonia, 115 patients, who received LMWH were included in the study. The mean age was 58.6 ± 13.3 and 58 (50.4 %) of the patients were male. Sixty-nine (60 %) of the patients were treated with prophylactic and 46 (40 %) therapeutic LMWH.In-hospital mortality was not different between patients treated therapeutic LMWH and prophylactic LMWH by the multivariate regression analysis (OR=2.187, 95% CI 0.484-9.880, p=0.309) and the propensity score modelling (OR=1.586, 95% CI 0.400-6.289, p=0.512.)CONCLUSION:
Clinicians should consider the potential risks and benefits of standard prophylactic and pre-emptive therapeutic LMWH. Therefore, anticoagulant therapy should be individualized in patients with COVID-19 (Tab. 3, Ref. 28).ключевые слова
Полный текст:
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Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Heparin, Low-Molecular-Weight
/
COVID-19
/
Anticoagulants
Тип исследования:
Наблюдательное исследование
/
Прогностическое исследование
Пределы темы:
Люди
/
Мужчины
/
Middle aged
Язык:
английский
Журнал:
Bratisl Lek Listy
Год:
2021
Тип:
Статья
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