Profile of Immunoglobulin G N-Glycome in COVID-19 Patients: A Case-Control Study.
Front Immunol
; 12: 748566, 2021.
Статья
в английский
| MEDLINE | ID: covidwho-1463474
ABSTRACT
Coronavirus disease 2019 (COVID-19) remains a major health challenge globally. Previous studies have suggested that changes in the glycosylation of IgG are closely associated with the severity of COVID-19. This study aimed to compare the profiles of IgG N-glycome between COVID-19 patients and healthy controls. A case-control study was conducted, in which 104 COVID-19 patients and 104 age- and sex-matched healthy individuals were recruited. Serum IgG N-glycome composition was analyzed by hydrophilic interaction liquid chromatography with the ultra-high-performance liquid chromatography (HILIC-UPLC) approach. COVID-19 patients have a decreased level of IgG fucosylation, which upregulates antibody-dependent cell cytotoxicity (ADCC) in acute immune responses. In severe cases, a low level of IgG sialylation contributes to the ADCC-regulated enhancement of inflammatory cytokines. The decreases in sialylation and galactosylation play a role in COVID-19 pathogenesis via the activation of the lectin-initiated alternative complement pathway. IgG N-glycosylation underlines the complex clinical phenotypes of SARS-CoV-2 infection.
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Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Immunoglobulin G
/
SARS-CoV-2
/
COVID-19
Тип исследования:
Наблюдательное исследование
/
Прогностическое исследование
Пределы темы:
Взрослые
/
Женщины
/
Люди
/
Мужчины
/
Middle aged
Язык:
английский
Журнал:
Front Immunol
Год:
2021
Тип:
Статья
Аффилированная страна:
Fimmu.2021.748566
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