The pathogenesis, epidemiology and biomarkers of susceptibility of pulmonary fibrosis in COVID-19 survivors.
Clin Chem Lab Med
; 60(3): 307-316, 2022 02 23.
Статья
в английский
| MEDLINE | ID: covidwho-1518385
ABSTRACT
Pulmonary fibrosis (PF), a pathological outcome of chronic and acute interstitial lung diseases associated to compromised wound healing, is a key component of the "post-acute COVID-19 syndrome" that may severely complicate patients' clinical course. Although inconclusive, available data suggest that more than a third of hospitalized COVID-19 patients develop lung fibrotic abnormalities after their discharge from hospital. The pathogenesis of PF in patients recovering from a severe acute case of COVID-19 is complex, and several hypotheses have been formulated to explain its development. An analysis of the data that is presently available suggests that biomarkers of susceptibility could help to identify subjects with increased probability of developing PF and may represent a means to personalize the management of COVID-19's long-term effects. Our review highlights the importance of both patient-related and disease-related contributing risk factors for PF in COVID-19 survivors and makes it definitely clear the possible use of acute phase and follow-up biomarkers for identifying the patients at greatest risk of developing this disease.
ключевые слова
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Pulmonary Fibrosis
/
COVID-19
Тип исследования:
Когортное исследование
/
Наблюдательное исследование
/
Прогностическое исследование
Темы:
Длинный Ковид
Пределы темы:
Люди
Язык:
английский
Журнал:
Clin Chem Lab Med
Тематика журнала:
Химия, клиническая
/
Лабораторные методы и процедуры
Год:
2022
Тип:
Статья
Аффилированная страна:
Cclm-2021-1021
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