Abnormal immunothrombosis and lupus anticoagulant in a catastrophic COVID-19 recalling Asherson's syndrome.
J Thromb Thrombolysis
; 52(4): 1043-1046, 2021 Nov.
Статья
в английский
| MEDLINE | ID: covidwho-1525570
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) is a complex disease with many clinicopathological aspects, including abnormal immunothrombosis, and the full comprehension of its pathogenetic mechanisms is urgently required. METHODS/RESULTS:
By means of a multidisciplinary approach, we here report a catastrophic COVID-19 in a 44-year-old Philippine male patient, discovered lupus anticoagulant (LAC)-positive shortly before death, occurred 8 days after hospitalization in a clinical scenario refractory to standard high acuity care recalling Asherson's syndrome (catastrophic antiphospholipid syndrome).CONCLUSION:
A parallelism between this severe form of COVID-19 and Asherson's syndrome can be so drawn. Both the diseases in fact exhibit hypercytokinemia, thrombotic microangiopathy, disseminated intravascular coagulation and multiple organ failure, they show a relationship with viral infections, and they are burdened by a high mortality rate. A genetic predisposition to develop these two overlapping conditions may be supposed.ключевые слова
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Lupus Coagulation Inhibitor
/
Antiphospholipid Syndrome
/
COVID-19
/
Thromboinflammation
Тип исследования:
История болезни
/
Экспериментальные исследования
/
Прогностическое исследование
Пределы темы:
Взрослые
/
Люди
/
Мужчины
Язык:
английский
Журнал:
J Thromb Thrombolysis
Тематика журнала:
Болезни системы кровообращения
Год:
2021
Тип:
Статья
Аффилированная страна:
S11239-021-02444-0
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