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Abnormal immunothrombosis and lupus anticoagulant in a catastrophic COVID-19 recalling Asherson's syndrome.
Roncati, Luca; Corsi, Lorenzo; Barbolini, Giuseppe.
  • Roncati L; Department of Surgery, Medicine Dentistry and Morphological Sciences with Interest in Transplantation, Oncology and Regenerative Medicine, Institute of Pathology, University of Modena and Reggio Emilia, Polyclinic Hospital, Largo del Pozzo 71, 41124, Modena (MO), Italy. luca.roncati@unimore.it.
  • Corsi L; Department of Life Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, Modena, Italy.
  • Barbolini G; Department of Surgery, Medicine Dentistry and Morphological Sciences with Interest in Transplantation, Oncology and Regenerative Medicine, Institute of Pathology, University of Modena and Reggio Emilia, Polyclinic Hospital, Largo del Pozzo 71, 41124, Modena (MO), Italy.
J Thromb Thrombolysis ; 52(4): 1043-1046, 2021 Nov.
Статья в английский | MEDLINE | ID: covidwho-1525570
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19) is a complex disease with many clinicopathological aspects, including abnormal immunothrombosis, and the full comprehension of its pathogenetic mechanisms is urgently required. METHODS/

RESULTS:

By means of a multidisciplinary approach, we here report a catastrophic COVID-19 in a 44-year-old Philippine male patient, discovered lupus anticoagulant (LAC)-positive shortly before death, occurred 8 days after hospitalization in a clinical scenario refractory to standard high acuity care recalling Asherson's syndrome (catastrophic antiphospholipid syndrome).

CONCLUSION:

A parallelism between this severe form of COVID-19 and Asherson's syndrome can be so drawn. Both the diseases in fact exhibit hypercytokinemia, thrombotic microangiopathy, disseminated intravascular coagulation and multiple organ failure, they show a relationship with viral infections, and they are burdened by a high mortality rate. A genetic predisposition to develop these two overlapping conditions may be supposed.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Lupus Coagulation Inhibitor / Antiphospholipid Syndrome / COVID-19 / Thromboinflammation Тип исследования: История болезни / Экспериментальные исследования / Прогностическое исследование Пределы темы: Взрослые / Люди / Мужчины Язык: английский Журнал: J Thromb Thrombolysis Тематика журнала: Болезни системы кровообращения Год: 2021 Тип: Статья Аффилированная страна: S11239-021-02444-0

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Lupus Coagulation Inhibitor / Antiphospholipid Syndrome / COVID-19 / Thromboinflammation Тип исследования: История болезни / Экспериментальные исследования / Прогностическое исследование Пределы темы: Взрослые / Люди / Мужчины Язык: английский Журнал: J Thromb Thrombolysis Тематика журнала: Болезни системы кровообращения Год: 2021 Тип: Статья Аффилированная страна: S11239-021-02444-0