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Beyond Lipoprotein(a) plasma measurements: Lipoprotein(a) and inflammation.
Reyes-Soffer, Gissette; Westerterp, Marit.
  • Reyes-Soffer G; Columbia University Medical Center, College of Physicians and Surgeons, Department of Medicine, Division of Preventive Medicine and Nutrition, New York, NY, USA. Electronic address: gr2104@cumc.columbia.edu.
  • Westerterp M; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address: m.westerterp@umcg.nl.
Pharmacol Res ; 169: 105689, 2021 07.
Статья в английский | MEDLINE | ID: covidwho-1525917
ABSTRACT
Genome wide association, epidemiological, and clinical studies have established high lipoprotein(a) [Lp(a)] as a causal risk factor for atherosclerotic cardiovascular disease (ASCVD). Lp(a) is an apoB100 containing lipoprotein covalently bound to apolipoprotein(a) [apo(a)], a glycoprotein. Plasma Lp(a) levels are to a large extent determined by genetics. Its link to cardiovascular disease (CVD) may be driven by its pro-inflammatory effects, of which its association with oxidized phospholipids (oxPL) bound to Lp(a) is the most studied. Various inflammatory conditions, such as rheumatoid arthritis (RA), systemic lupus erythematosus, acquired immunodeficiency syndrome, and chronic renal failure are associated with high Lp(a) levels. In cases of RA, high Lp(a) levels are reversed by interleukin-6 receptor (IL-6R) blockade by tocilizumab, suggesting a potential role for IL-6 in regulating Lp(a) plasma levels. Elevated levels of IL-6 and IL-6R polymorphisms are associated with CVD. Therapies aimed at lowering apo(a) and thereby reducing plasma Lp(a) levels are in clinical trials. Their results will determine if reductions in apo(a) and Lp(a) decrease cardiovascular outcomes. As we enter this new arena of available treatments, there is a need to improve our understanding of mechanisms. This review will focus on the role of Lp(a) in inflammation and CVD.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Lipoprotein(a) / Inflammation Тип исследования: Прогностическое исследование Пределы темы: Животные / Люди Язык: английский Журнал: Pharmacol Res Тематика журнала: Фармакология Год: 2021 Тип: Статья

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Lipoprotein(a) / Inflammation Тип исследования: Прогностическое исследование Пределы темы: Животные / Люди Язык: английский Журнал: Pharmacol Res Тематика журнала: Фармакология Год: 2021 Тип: Статья