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IL-6 and other biomarkers as predictors of severity in COVID-19.
Broman, N; Rantasärkkä, K; Feuth, T; Valtonen, M; Waris, M; Hohenthal, U; Rintala, E; Karlsson, A; Marttila, H; Peltola, V; Vuorinen, T; Oksi, J.
  • Broman N; Department of Infectious Diseases, Turku University Hospital, Turku, Finland.
  • Rantasärkkä K; Department of Clinical Microbiology, Turku University Hospital and Institute of Biomedicine, University of Turku, Turku, Finland.
  • Feuth T; Department of Pulmonary Diseases, Turku University Hospital and Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland.
  • Valtonen M; Department of Anaesthesia and Intensive Care, Turku University Hospital, Turku, Finland.
  • Waris M; Department of Clinical Microbiology, Turku University Hospital and Institute of Biomedicine, University of Turku, Turku, Finland.
  • Hohenthal U; Department of Infectious Diseases, Turku University Hospital and University of Turku, Turku, Finland.
  • Rintala E; Department of Hospital Hygiene and Infection Control, Turku University Hospital, Turku, Finland.
  • Karlsson A; Auria Biobank, Turku University Hospital and University of Turku, Turku, Finland.
  • Marttila H; Department of Hospital Hygiene and Infection Control, Turku University Hospital, Turku, Finland.
  • Peltola V; Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
  • Vuorinen T; Department of Clinical Microbiology, Turku University Hospital and Institute of Biomedicine, University of Turku, Turku, Finland.
  • Oksi J; Department of Infectious Diseases, Turku University Hospital and University of Turku, Turku, Finland.
Ann Med ; 53(1): 410-412, 2021 12.
Статья в английский | MEDLINE | ID: covidwho-1573909
ABSTRACT

OBJECTIVE:

Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers.

METHODS:

We studied markers of inflammation and coagulation as recorded in 29 patients on admission to the hospital in order to identify markers of severe COVID-19 and need of ICU.

RESULTS:

Patients who were eventually admitted to ICU displayed significantly higher serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin. No statistical differences were found between the groups in median levels of lymphocytes, D-dimer or ferritin.

CONCLUSIONS:

IL-6 and CRP were the strongest predictors of severity in hospitalized patients with COVID-19.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Interleukin-6 / COVID-19 Тип исследования: Диагностическое исследование / Экспериментальные исследования / Прогностическое исследование / Рандомизированные контролируемые испытания Пределы темы: Подростки / Взрослые / Пожилые / Женщины / Люди / Мужчины / Middle aged / Молодой взрослый Язык: английский Журнал: Ann Med Тематика журнала: Медицина Год: 2021 Тип: Статья Аффилированная страна: 07853890.2020.1840621

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Interleukin-6 / COVID-19 Тип исследования: Диагностическое исследование / Экспериментальные исследования / Прогностическое исследование / Рандомизированные контролируемые испытания Пределы темы: Подростки / Взрослые / Пожилые / Женщины / Люди / Мужчины / Middle aged / Молодой взрослый Язык: английский Журнал: Ann Med Тематика журнала: Медицина Год: 2021 Тип: Статья Аффилированная страна: 07853890.2020.1840621