Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection.
Gut
; 69(6): 997-1001, 2020 06.
Статья
в английский
| MEDLINE | ID: covidwho-1723830
ABSTRACT
OBJECTIVE:
To study the GI symptoms in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients.DESIGN:
We analysed epidemiological, demographic, clinical and laboratory data of 95 cases with SARS-CoV-2 caused coronavirus disease 2019. Real-time reverse transcriptase PCR was used to detect the presence of SARS-CoV-2 in faeces and GI tissues.RESULTS:
Among the 95 patients, 58 cases exhibited GI symptoms of which 11 (11.6%) occurred on admission and 47 (49.5%) developed during hospitalisation. Diarrhoea (24.2%), anorexia (17.9%) and nausea (17.9%) were the main symptoms with five (5.3%), five (5.3%) and three (3.2%) cases occurred on the illness onset, respectively. A substantial proportion of patients developed diarrhoea during hospitalisation, potentially aggravated by various drugs including antibiotics. Faecal samples of 65 hospitalised patients were tested for the presence of SARS-CoV-2, including 42 with and 23 without GI symptoms, of which 22 (52.4%) and 9 (39.1%) were positive, respectively. Six patients with GI symptoms were subjected to endoscopy, revealing oesophageal bleeding with erosions and ulcers in one severe patient. SARS-CoV-2 RNA was detected in oesophagus, stomach, duodenum and rectum specimens for both two severe patients. In contrast, only duodenum was positive in one of the four non-severe patients.CONCLUSIONS:
GI tract may be a potential transmission route and target organ of SARS-CoV-2.ключевые слова
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Pneumonia, Viral
/
Coronavirus Infections
/
Gastrointestinal Tract
/
Pandemics
/
Betacoronavirus
Тип исследования:
Наблюдательное исследование
/
Прогностическое исследование
Пределы темы:
Взрослые
/
Женщины
/
Люди
/
Мужчины
/
Middle aged
Язык:
английский
Журнал:
Gut
Год:
2020
Тип:
Статья
Аффилированная страна:
Gutjnl-2020-321013
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