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Targeting inflammation with collagen.
Schwarz, Dennis; Lipoldová, Marie; Reinecke, Holger; Sohrabi, Yahya.
  • Schwarz D; Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
  • Lipoldová M; Laboratory of Signal Transduction, Institutes of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
  • Reinecke H; Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
  • Sohrabi Y; Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
Clin Transl Med ; 12(5): e831, 2022 05.
Статья в английский | MEDLINE | ID: covidwho-1858584
ABSTRACT
Tissue damage caused by an infection oran autoimmune disease triggers degradation of collagen in the extracellular matrix (ECM), which further enhances inflammation. Therefore, improving ECM in aninflamed tissue can be exploited as a potential therapeutic target. A recentstudy emphasised an innovative approach against COVID-19 using polymerised type I collagen (PTIC) that improves disease severity through a hitherto unknownmechanism. In this paper, we provide an overview of potential mechanism thatmay explain the anti-inflammatory effect of collagen peptides. In addition,the paper includes a brief summary of possible side effect of collagendeposition in inflammatory diseases. Altogether, current knowledge suggeststhat collagen may potentially reduce the residual risk in inflammatorydiseases; however, the detailed mechanism remains elusive.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: COVID-19 Drug Treatment Тип исследования: Прогностическое исследование Пределы темы: Люди Язык: английский Журнал: Clin Transl Med Год: 2022 Тип: Статья Аффилированная страна: Ctm2.831

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: COVID-19 Drug Treatment Тип исследования: Прогностическое исследование Пределы темы: Люди Язык: английский Журнал: Clin Transl Med Год: 2022 Тип: Статья Аффилированная страна: Ctm2.831