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Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study.
Rovas, Alexandros; Buscher, Konrad; Osiaevi, Irina; Drost, Carolin Christina; Sackarnd, Jan; Tepasse, Phil-Robin; Fobker, Manfred; Kühn, Joachim; Braune, Stephan; Göbel, Ulrich; Thölking, Gerold; Gröschel, Andreas; Rossaint, Jan; Vink, Hans; Lukasz, Alexander; Pavenstädt, Hermann; Kümpers, Philipp.
  • Rovas A; Department of Medicine D, Division of General Internal and Emergency Medicine, Nephrology, and Rheumatology, University Hospital Münster, Albert-Schweitzer Campus 1, 48149, Münster, Germany.
  • Buscher K; Department of Medicine D, Division of General Internal and Emergency Medicine, Nephrology, and Rheumatology, University Hospital Münster, Albert-Schweitzer Campus 1, 48149, Münster, Germany.
  • Osiaevi I; Department of Medicine D, Division of General Internal and Emergency Medicine, Nephrology, and Rheumatology, University Hospital Münster, Albert-Schweitzer Campus 1, 48149, Münster, Germany.
  • Drost CC; Department of Medicine A, Hematology, Oncology and Pulmonary Medicine, University Hospital Münster, Albert-Schweitzer Campus 1, 48149, Münster, Germany.
  • Sackarnd J; Department of Medicine D, Division of General Internal and Emergency Medicine, Nephrology, and Rheumatology, University Hospital Münster, Albert-Schweitzer Campus 1, 48149, Münster, Germany.
  • Tepasse PR; Department of Cardiology and Angiology, University Hospital Münster, Albert-Schweitzer Campus 1, 48149, Münster, Germany.
  • Fobker M; Department of Medicine B for Gastroenterology, Hepatology, Endocrinology, Clinical Infectiology, University Hospital Münster, Albert-Schweitzer Campus 1, 48149, Münster, Germany.
  • Kühn J; Center for Laboratory Medicine, University Hospital Münster, Albert-Schweitzer Campus 1, 48149, Münster, Germany.
  • Braune S; Institute of Virology, University Hospital Münster, Von-Stauffenberg-Straße 36, 48151, Münster, Germany.
  • Göbel U; Departmenf of Intensive Care and Emergency Medicine, St. Franziskus-Hospital GmbH, Hohenzollernring 70, 48145, Münster, Germany.
  • Thölking G; Department of Anaesthesiology and Critical Care, St. Franziskus-Hospital GmbH, Hohenzollernring 70, 48145, Münster, Germany.
  • Gröschel A; Department of Medicine D, Division of General Internal and Emergency Medicine, Nephrology, and Rheumatology, University Hospital Münster, Albert-Schweitzer Campus 1, 48149, Münster, Germany.
  • Rossaint J; Department of Internal Medicine and Nephrology, University Hospital Münster Marienhospital Steinfurt, Mauritiusstr. 5, 48565, Steinfurt, Germany.
  • Vink H; Department of Pulmonology, Clemens Hospital, Düesbergweg 124, 48153, Münster, Germany.
  • Lukasz A; Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Albert-Schweitzer Campus 1, 48149, Münster, Germany.
  • Pavenstädt H; Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, 6229 ER, Maastricht, the Netherlands.
  • Kümpers P; Department of Medicine D, Division of General Internal and Emergency Medicine, Nephrology, and Rheumatology, University Hospital Münster, Albert-Schweitzer Campus 1, 48149, Münster, Germany.
Angiogenesis ; 25(4): 503-515, 2022 11.
Статья в английский | MEDLINE | ID: covidwho-1899208
ABSTRACT

AIMS:

Although coronavirus disease 2019 (COVID-19) and bacterial sepsis are distinct conditions, both are known to trigger endothelial dysfunction with corresponding microcirculatory impairment. The purpose of this study was to compare microvascular injury patterns and proteomic signatures in COVID-19 and bacterial sepsis patients. METHODS AND

RESULTS:

This multi-center, observational study included 22 hospitalized adult COVID-19 patients, 43 hospitalized bacterial sepsis patients, and 10 healthy controls from 4 hospitals. Microcirculation and glycocalyx dimensions were quantified via intravital sublingual microscopy. Plasma proteins were measured using targeted proteomics (Olink). Coregulation and cluster analysis of plasma proteins was performed using a training-set and confirmed in a test-set. An independent external cohort of 219 COVID-19 patients was used for validation and outcome analysis. Microcirculation and plasma proteome analysis found substantial overlap between COVID-19 and bacterial sepsis. Severity, but not disease entity explained most data variation. Unsupervised correlation analysis identified two main coregulated plasma protein signatures in both diseases that strictly counteract each other. They were associated with microvascular dysfunction and several established markers of clinical severity. The signatures were used to derive new composite biomarkers of microvascular injury that allow to predict 28-day mortality or/and intubation (area under the curve 0.90, p < 0.0001) in COVID-19.

CONCLUSION:

Our data imply a common biological host response of microvascular injury in both bacterial sepsis and COVID-19. A distinct plasma signature correlates with endothelial health and improved outcomes, while a counteracting response is associated with glycocalyx breakdown and high mortality. Microvascular health biomarkers are powerful predictors of clinical outcomes.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Sepsis / COVID-19 Тип исследования: Когортное исследование / Наблюдательное исследование / Прогностическое исследование Пределы темы: Взрослые / Люди Язык: английский Журнал: Angiogenesis Тематика журнала: Гематология Год: 2022 Тип: Статья Аффилированная страна: S10456-022-09843-8

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Sepsis / COVID-19 Тип исследования: Когортное исследование / Наблюдательное исследование / Прогностическое исследование Пределы темы: Взрослые / Люди Язык: английский Журнал: Angiogenesis Тематика журнала: Гематология Год: 2022 Тип: Статья Аффилированная страна: S10456-022-09843-8