Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Nat Med
; 26(6): 842-844, 2020 06.
Статья
в английский
| MEDLINE | ID: covidwho-1900503
ABSTRACT
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Pneumonia, Viral
/
Coronavirus Infections
/
Single-Cell Analysis
/
Betacoronavirus
Тип исследования:
Диагностическое исследование
/
Прогностическое исследование
Пределы темы:
Люди
Язык:
английский
Журнал:
Nat Med
Тематика журнала:
Молекулярная биология
/
Медицина
Год:
2020
Тип:
Статья
Аффилированная страна:
S41591-020-0901-9
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