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Biomarker candidates for progression and clinical management of COVID-19 associated pneumonia at time of admission.
Calvet, Joan; Berenguer-Llergo, Antoni; Gay, Marina; Massanella, Marta; Domingo, Pere; Llop, Maria; Sánchez-Jiménez, Ester; Arévalo, Marta; Carrillo, Jorge; Albiñana, Néstor; Arauz-Garofalo, Gianluca; Orellana, Cristóbal; Delgado, Juan Francisco; Serrano, Alejandra; Llobell, Artur; Graell, Eduard; García-Manrique, María; Moreno, Mireia; Galisteo, Carlos; Casado, Enrique; Navarro, Noemí; Gómez, Antoni; Garcia-Cirera, Silvia; Rusiñol, Menna; Costa, Ester; Clotet, Bonaventura; Vilaseca, Marta; Blanco, Julià; Gratacós, Jordi.
  • Calvet J; Rheumatology Department, Parc Taulí Hospital Universitari, c/Parc Taulí S/N, Edifici VII Centenari Rheumatology Department, 08208, Sabadell, Spain.
  • Berenguer-Llergo A; Institut d'Investigació i Innovació Parc Taulí (I3PT), 08208, Sabadell, Spain.
  • Gay M; Departament de Medicina, Universitat Autónoma de Barcelona (UAB), 08003, Barcelona, Spain.
  • Massanella M; Institute for Research in Biomedicine Barcelona (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028, Barcelona, Spain.
  • Domingo P; Institute for Research in Biomedicine Barcelona (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028, Barcelona, Spain.
  • Llop M; IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain.
  • Sánchez-Jiménez E; Infectious Diseases Department, Hospital de la Santa Creu i Sant Pau. Institut de Recerca Biomèdica del HSCSP Barcelona, Barcelona, Spain.
  • Arévalo M; Rheumatology Department, Parc Taulí Hospital Universitari, c/Parc Taulí S/N, Edifici VII Centenari Rheumatology Department, 08208, Sabadell, Spain.
  • Carrillo J; Institut d'Investigació i Innovació Parc Taulí (I3PT), 08208, Sabadell, Spain.
  • Albiñana N; Institute for Research in Biomedicine Barcelona (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028, Barcelona, Spain.
  • Arauz-Garofalo G; Rheumatology Department, Parc Taulí Hospital Universitari, c/Parc Taulí S/N, Edifici VII Centenari Rheumatology Department, 08208, Sabadell, Spain.
  • Orellana C; Institut d'Investigació i Innovació Parc Taulí (I3PT), 08208, Sabadell, Spain.
  • Delgado JF; IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain.
  • Serrano A; Institut d'Investigació i Innovació Parc Taulí (I3PT), 08208, Sabadell, Spain.
  • Llobell A; Institute for Research in Biomedicine Barcelona (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028, Barcelona, Spain.
  • Graell E; Rheumatology Department, Parc Taulí Hospital Universitari, c/Parc Taulí S/N, Edifici VII Centenari Rheumatology Department, 08208, Sabadell, Spain.
  • García-Manrique M; Institut d'Investigació i Innovació Parc Taulí (I3PT), 08208, Sabadell, Spain.
  • Moreno M; UDIAT Immunology Unit, Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT), 08208, Sabadell, Spain.
  • Galisteo C; Institut d'Investigació i Innovació Parc Taulí (I3PT), 08208, Sabadell, Spain.
  • Casado E; Rheumatology Department, Parc Taulí Hospital Universitari, c/Parc Taulí S/N, Edifici VII Centenari Rheumatology Department, 08208, Sabadell, Spain.
  • Navarro N; Institut d'Investigació i Innovació Parc Taulí (I3PT), 08208, Sabadell, Spain.
  • Gómez A; Rheumatology Department, Parc Taulí Hospital Universitari, c/Parc Taulí S/N, Edifici VII Centenari Rheumatology Department, 08208, Sabadell, Spain.
  • Garcia-Cirera S; Institut d'Investigació i Innovació Parc Taulí (I3PT), 08208, Sabadell, Spain.
  • Rusiñol M; Rheumatology Department, Parc Taulí Hospital Universitari, c/Parc Taulí S/N, Edifici VII Centenari Rheumatology Department, 08208, Sabadell, Spain.
  • Costa E; Institut d'Investigació i Innovació Parc Taulí (I3PT), 08208, Sabadell, Spain.
  • Clotet B; Rheumatology Department, Parc Taulí Hospital Universitari, c/Parc Taulí S/N, Edifici VII Centenari Rheumatology Department, 08208, Sabadell, Spain.
  • Vilaseca M; Institut d'Investigació i Innovació Parc Taulí (I3PT), 08208, Sabadell, Spain.
  • Blanco J; Rheumatology Department, Parc Taulí Hospital Universitari, c/Parc Taulí S/N, Edifici VII Centenari Rheumatology Department, 08208, Sabadell, Spain.
  • Gratacós J; Institut d'Investigació i Innovació Parc Taulí (I3PT), 08208, Sabadell, Spain.
Sci Rep ; 12(1): 640, 2022 01 12.
Статья в английский | MEDLINE | ID: covidwho-1900548
ABSTRACT
COVID-19 pathophysiology is currently not fully understood, reliable prognostic factors remain elusive, and few specific therapeutic strategies have been proposed. In this scenario, availability of biomarkers is a priority. MS-based Proteomics techniques were used to profile the proteome of 81 plasma samples extracted in four consecutive days from 23 hospitalized COVID-19 associated pneumonia patients. Samples from 10 subjects that reached a critical condition during their hospital stay and 10 matched non-severe controls were drawn before the administration of any COVID-19 specific treatment and used to identify potential biomarkers of COVID-19 prognosis. Additionally, we compared the proteome of five patients before and after glucocorticoids and tocilizumab treatment, to assess the changes induced by the therapy on our selected candidates. Forty-two proteins were differentially expressed between patients' evolution groups at 10% FDR. Twelve proteins showed lower levels in critical patients (fold-changes 1.20-3.58), of which OAS3 and COG5 found their expression increased after COVID-19 specific therapy. Most of the 30 proteins over-expressed in critical patients (fold-changes 1.17-4.43) were linked to inflammation, coagulation, lipids metabolism, complement or immunoglobulins, and a third of them decreased their expression after treatment. We propose a set of candidate proteins for biomarkers of COVID-19 prognosis at the time of hospital admission. The study design employed is distinctive from previous works and aimed to optimize the chances of the candidates to be validated in confirmatory studies and, eventually, to play a useful role in the clinical practice.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Blood Proteins / COVID-19 / Hospitalization Тип исследования: Когортное исследование / Диагностическое исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Пределы темы: Пожилые / Женщины / Люди / Мужчины / Middle aged Язык: английский Журнал: Sci Rep Год: 2022 Тип: Статья Аффилированная страна: S41598-021-04683-w

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Blood Proteins / COVID-19 / Hospitalization Тип исследования: Когортное исследование / Диагностическое исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Пределы темы: Пожилые / Женщины / Люди / Мужчины / Middle aged Язык: английский Журнал: Sci Rep Год: 2022 Тип: Статья Аффилированная страна: S41598-021-04683-w