The role of angiotensin-converting enzyme 2 in the pathogenesis of COVID-19: the villain or the hero?
Acta Clin Belg
; 77(1): 211-218, 2022 Feb.
Статья
в английский
| MEDLINE | ID: covidwho-1900965
ABSTRACT
Angiotensin-converting enzyme 2 (ACE 2) is the entry receptor for the novel coronavirus SARS-CoV-2, the aetiological agent of COVID-19. At the same time, ACE 2 expression decreases during COVID-19. Two seemingly contradictory relationships between the expression of ACE 2 and COVID-19 have been reported. Increased level of expression of ACE 2 may be a risk factor for the development of COVID-19 infection, while reduced ACE 2 expression during COVID-19 leads to acute respiratory distress syndrome. This article provides a comprehensive overview of available scientific knowledge about the role of ACE 2 in the pathogenesis of COVID-19, which is available up to current day. Also, it discusses unknown factors that we will have to reveal in order to understand the whole role of ACE 2 in the pathogenesis of COVID-19.
ключевые слова
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Angiotensin-Converting Enzyme 2
/
COVID-19
Тип исследования:
Изучение этиологии
/
Прогностическое исследование
Пределы темы:
Люди
Язык:
английский
Журнал:
Acta Clin Belg
Год:
2022
Тип:
Статья
Аффилированная страна:
17843286.2020.1786324
Документы, близкие по теме
MEDLINE
...
LILACS
LIS