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Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?
Agrawal, Pawan K; Agrawal, Chandan; Blunden, Gerald.
  • Agrawal PK; Natural Product Inc., 7963 Anderson Park Lane, Westerville, OH 43081, USA.
  • Agrawal C; Natural Product Inc., 7963 Anderson Park Lane, Westerville, OH 43081, USA.
  • Blunden G; School of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth PO1 2DT, UK.
Molecules ; 27(12)2022 Jun 14.
Статья в английский | MEDLINE | ID: covidwho-1911482
ABSTRACT
As the world desperately searches for ways to treat the coronavirus disease 2019 (COVID-19) pandemic, a growing number of people are turning to herbal remedies. The Artemisia species, such as A. annua and A. afra, in particular, exhibit positive effects against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and COVID-19 related symptoms. A. annua is a source of artemisinin, which is active against malaria, and also exhibits potential for other diseases. This has increased interest in artemisinin's potential for drug repurposing. Artemisinin-based combination therapies, so-called ACTs, have already been recognized as first-line treatments against malaria. Artemisia extract, as well as ACTs, have demonstrated inhibition of SARS-CoV-2. Artemisinin and its derivatives have also shown anti-inflammatory effects, including inhibition of interleukin-6 (IL-6) that plays a key role in the development of severe COVID-19. There is now sufficient evidence in the literature to suggest the effectiveness of Artemisia, its constituents and/or artemisinin derivatives, to fight against the SARS-CoV-2 infection by inhibiting its invasion, and replication, as well as reducing oxidative stress and inflammation, and mitigating lung damage.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Artemisia / Artemisia annua / Artemisinins / COVID-19 Drug Treatment / Malaria / Antimalarials Тип исследования: Экспериментальные исследования Темы: Традиционная медицина Пределы темы: Люди Язык: английский Тематика журнала: Биология Год: 2022 Тип: Статья Аффилированная страна: Molecules27123828

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Artemisia / Artemisia annua / Artemisinins / COVID-19 Drug Treatment / Malaria / Antimalarials Тип исследования: Экспериментальные исследования Темы: Традиционная медицина Пределы темы: Люди Язык: английский Тематика журнала: Биология Год: 2022 Тип: Статья Аффилированная страна: Molecules27123828