Multifocal lymphadenopathies with polyclonal reactions primed after EBV infection in a mRNA-1273 vaccine recipient.
Swiss Med Wkly
; 152: w30188, 2022 05 23.
Статья
в английский
| MEDLINE | ID: covidwho-1911928
ABSTRACT
We report a case of recurrent tender, multifocal lymphadenopathies associated with B-symptoms, clinically mimicking lymphoma in a mRNA-1273 vaccine recipient after a recent Epstein-Barr virus (EBV) infection. In the lymph node biopsy, monocytoid B-cell hyperplasia, TH2 (GATA3+) predominance, and hyperplasia of interferon-gamma-producing plasmacytoid dendritic cells were observed along with sustained neutralising antibody production against SARS-CoV-2 wild-type and five variants. High titres of anti-S antibodies and neutralising antibodies were observed, excepted for variant B.1.529** (omicron) and B.1.351** (beta), due to several mutations in the spike protein, including the E484K mutation. We postulated that EBV acted as an immunological enhancer with the mRNA-1273 vaccine, inducing a sustained inflammatory response over several weeks. However, the polyclonal nature of the lymphadenopathy with polytypic plasmacytosis and pseudo-tumoural reaction cell hyperplasia were associated with failure to mount acute phase responses.
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Epstein-Barr Virus Infections
/
Lymphadenopathy
/
COVID-19
Тип исследования:
История болезни
/
Прогностическое исследование
Темы:
Длинный Ковид
/
Вакцина
/
Варианты
Пределы темы:
Люди
Язык:
английский
Журнал:
Swiss Med Wkly
Тематика журнала:
Медицина
Год:
2022
Тип:
Статья
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