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A community based cross sectional study on the prevalence of dyslipidemias and 10 years cardiovascular risk scores in adults in Asmara, Eritrea.
Achila, Oliver Okoth; Fessahye, Nahom; Mengistu, Samuel Tekle; Habtemikael, Naemi Tesfamariam; Werke, Wintana Yebio; Zemichael, Femal Tesfazghi; Leghese, Haben Negash; Weldegegish, Thomas Amanuel; Tekeste, Tsegay Habteab; Garoy, Eyob Yohannes.
  • Achila OO; Orotta College of Medicine and Health Sciences, Asmara, Eritrea.
  • Fessahye N; Orotta College of Medicine and Health Sciences, Asmara, Eritrea.
  • Mengistu ST; Orotta College of Medicine and Health Sciences, Asmara, Eritrea. teklesam7@gmail.com.
  • Habtemikael NT; Nakfa Hospital, Ministry of Health Northern Red Sea Branch, Nakfa, Eritrea. teklesam7@gmail.com.
  • Werke WY; Orotta College of Medicine and Health Sciences, Asmara, Eritrea.
  • Zemichael FT; Orotta College of Medicine and Health Sciences, Asmara, Eritrea.
  • Leghese HN; Orotta College of Medicine and Health Sciences, Asmara, Eritrea.
  • Weldegegish TA; Orotta College of Medicine and Health Sciences, Asmara, Eritrea.
  • Tekeste TH; Orotta College of Medicine and Health Sciences, Asmara, Eritrea.
  • Garoy EY; Orotta College of Medicine and Health Sciences, Asmara, Eritrea.
Sci Rep ; 12(1): 5567, 2022 04 02.
Статья в английский | MEDLINE | ID: covidwho-1931451
ABSTRACT
Despite the contribution of dyslipidemia to the high and rising burden of arteriosclerotic cardiovascular disease (CVD) in Sub-Saharan Africa; the condition is under-diagnosed, under-treated, and under-described. The objective of this study was to explore the prevalence of dyslipidemias, estimate a 10-year cardiovascular disease risk and associated factors in adults (≥ 35 to ≤ 85 years) living in Asmara, Eritrea. This population-based cross-sectional study was conducted among individuals without overt CVDs in Asmara, Eritrea, from October 2020 to November 2020. After stratified multistage sampling, a total of 386 (144 (37%) males and 242 (63%) females, mean age ± SD, 52.17 ± 13.29 years) respondents were randomly selected. The WHO NCD STEPS instrument version 3.1 questionnaire was used to collect data. Information on socio-demographic variables was collected via interviews by trained data collectors. Measurements/or analyses including anthropometric, lipid panel, fasting plasma glucose, and blood pressure were also undertaken. Finally, data was analyzed by using Statistical Package for Social Sciences version 26.0 for Windows (SPSS Inc., Chicago, IL, USA). All p-values were 2-sided and the level of significance was set at p < 0.05 for all analyses. The frequency of dyslipidemia in this population was disproportionately high (87.4%) with the worst affected subgroup in the 51-60 age band. Further, 98% of the study participants were not aware of their diagnosis. In terms of individual lipid markers, the proportions were as follows low HDL-C (55.2%); high TC (49.7%); high LDL (44.8%); high TG (38.1%). The mean ± SD, for HDL-C, TC, LDL-C, non-HDL-C, and TG were 45.28 ± 9.60; 205.24 ± 45.77; 130.77 ± 36.15; 160.22 ± 42.09 and 144.5 ± 61.26 mg/dL, respectively. Regarding NCEP ATP III risk criteria, 17.6%, 19.4%, 16.3%, 19.7%, and 54.7% were in high or very high-risk categories for TC, Non-HDL-C, TG, LDL-C, and HDL-C, respectively. Among all respondents, 59.6% had mixed dyslipidemias with TC + TG + LDL-C dominating. In addition, 27.3%, 28.04%, 23.0%, and 8.6% had abnormalities in 1, 2, 3 and 4 lipid abnormalities, respectively. Multivariate logistic regression modeling suggested that dyslipidemia was lower in subjects who were employed (aOR 0.48, 95% CI 0.24-0.97, p = 0.015); self-employed (aOR 0.41, 95% CI 0.17-1.00, p = 0.018); and married (aOR 2.35, 95% CI 1.19-4.66, p = 0.009). A higher likelihood of dyslipidemia was also associated with increasing DBP (aOR 1.04 mmHg (1.00-1.09, p = 0.001) and increasing FPG (aOR 1.02 per 1 mg/dL, 95% CI 1.00-1.05, p = 0.001). Separately, Framingham CVD Risk score estimates suggested that 12.7% and 2.8% were at 10 years CVD high risk or very high-risk strata. High frequency of poor lipid health may be a prominent contributor to the high burden of atherosclerotic CVDs-related mortality and morbidity in Asmara, Eritrea. Consequently, efforts directed at early detection, and evidence-based interventions are warranted. The low awareness rate also points at education within the population as a possible intervention pathway.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Cardiovascular Diseases / Dyslipidemias Тип исследования: Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Темы: Длинный Ковид Пределы темы: Взрослые / Женщины / Люди / Мужчины Страна как тема: Африка Язык: английский Журнал: Sci Rep Год: 2022 Тип: Статья Аффилированная страна: S41598-022-09446-9

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Cardiovascular Diseases / Dyslipidemias Тип исследования: Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Темы: Длинный Ковид Пределы темы: Взрослые / Женщины / Люди / Мужчины Страна как тема: Африка Язык: английский Журнал: Sci Rep Год: 2022 Тип: Статья Аффилированная страна: S41598-022-09446-9