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Dietary advanced glycation end-products elicit toxicological effects by disrupting gut microbiome and immune homeostasis.
Chen, Yingjia; Guo, Tai L.
  • Chen Y; Department of Biomedical Sciences, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
  • Guo TL; Department of Biomedical Sciences, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
J Immunotoxicol ; 18(1): 93-104, 2021 07 24.
Статья в английский | MEDLINE | ID: covidwho-1947806
ABSTRACT
The aging immune system is characterized by a low-grade chronic systemic inflammatory state ("inflammaging") marked by elevated serum levels of inflammatory molecules such as interleukin (IL)-6 and C-reactive protein (CRP). These inflammatory markers were also reported to be strong predictors for the development/severity of Type 2 diabetes, obesity, and COVID-19. The levels of these markers have been positively associated with those of advanced glycation end-products (AGEs) generated via non-enzymatic glycation and oxidation of proteins and lipids during normal aging and metabolism. Based on the above observations, it is clinically important to elucidate how dietary AGEs modulate inflammation and might thus increase the risk for aging-exacerbated diseases. The present narrative review discusses the potential pro-inflammatory properties of dietary AGEs with a focus on the inflammatory mediators CRP, IL-6 and ferritin, and their relations to aging in general and Type 2 diabetes in particular. In addition, underlying mechanisms - including those related to gut microbiota and the receptors for AGEs, and the roles AGEs might play in affecting physiologies of the healthy elderly, obese individuals, and diabetics are discussed in regard to any greater susceptibility to COVID-19.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Glycation End Products, Advanced / Inflammation Mediators / Diabetes Mellitus, Type 2 / SARS-CoV-2 / COVID-19 Тип исследования: Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Отзывы Пределы темы: Животные / Люди Язык: английский Журнал: J Immunotoxicol Тематика журнала: Аллергология и иммунология / Токсикология Год: 2021 Тип: Статья Аффилированная страна: 1547691X.2021.1959677

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Glycation End Products, Advanced / Inflammation Mediators / Diabetes Mellitus, Type 2 / SARS-CoV-2 / COVID-19 Тип исследования: Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Отзывы Пределы темы: Животные / Люди Язык: английский Журнал: J Immunotoxicol Тематика журнала: Аллергология и иммунология / Токсикология Год: 2021 Тип: Статья Аффилированная страна: 1547691X.2021.1959677