Pregnancy and COVID-19: The Possible Contribution of Vitamin D.
Nutrients
; 14(16)2022 Aug 10.
Статья
в английский
| MEDLINE | ID: covidwho-1979324
ABSTRACT
BACKGROUND:
Vitamin D deficiency has been associated with the severity of COVID-19. The role of vitamin D in pregnant women with COVID-19 has been poorly investigated to date. The aim of this study was to evaluate the influence of vitamin D in affecting some clinical features in pregnancy between SARS-CoV-2 positive and negative patients.METHODS:
Vitamin D pathway related polymorphisms and 25-hydroxyvitamin D levels were quantified in pregnant women followed from the first to the third trimester of pregnancy. Vitamin D deficiency was considered with values ≤ 30 ng/mL.RESULTS:
In total, 160 women were enrolled 23 resulted positive for at least one SARS-CoV-2 related test (molecular swab or antibody tests). Vitamin D-associated polymorphisms were able to affect vitamin D levels in SARS-CoV-2 negative and positivesubjects:
remarkably, all the VDR TaqICC genotype patients were negative for SARS-CoV-2. In a sub-population (118 patients), vitamin D levels correlated with pregnancy-related factors, such as alpha-fetoprotein levels. Third-trimester vitamin D levels were lower in preterm births compared to full-term pregnancy this trend was highlighted for SARS-CoV-2 positive patients.CONCLUSIONS:
This is the first study demonstrating a role of vitamin D in affecting the clinical characteristics of pregnant women during the COVID-19 era. Further studies in larger and different cohorts of patients are required to confirm these findings.ключевые слова
Полный текст:
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Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Vitamin D
/
Vitamin D Deficiency
/
Pregnancy
/
Premature Birth
/
COVID-19
Тип исследования:
Когортное исследование
/
Экспериментальные исследования
/
Наблюдательное исследование
/
Прогностическое исследование
Темы:
Длинный Ковид
Пределы темы:
Женщины
/
Люди
/
Новорожденные
/
Беременность
Язык:
английский
Год:
2022
Тип:
Статья
Аффилированная страна:
Nu14163275
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