A case of severe COVID-19 with pulmonary thromboembolism related to heparin-induced thrombocytopenia during prophylactic anticoagulation therapy.
J Infect Chemother
; 28(8): 1208-1211, 2022 Aug.
Статья
в английский
| MEDLINE | ID: covidwho-1983457
ABSTRACT
A 53-year-old male Japanese patient with COVID-19 was admitted to our hospital after his respiratory condition worsened on day 9 of the disease. With the diagnosis of severe COVID-19, treatment with remdesivir, dexamethasone, and unfractionated heparin was started for the prevention of thrombosis. Although the patient's respiratory status data improved after treatment, severe respiratory failure persisted. Thrombocytopenia and D-dimer elevation were observed on day 8 after heparin therapy initiation. Heparin-induced thrombocytopenia (HIT) antibody measured by immunological assay was positive, and contrast computed tomography showed pulmonary artery thrombus. The patient was diagnosed with HIT because the pre-test probability score (4Ts score) for HIT was 7 points. Heparin was changed to apixaban, a direct oral anticoagulant, which resulted in a reduction of the pulmonary thrombus and improvement of the respiratory failure. In patients with COVID-19, anticoagulant therapy with heparin requires careful monitoring of thrombocytopenia and elevated D-dimer as possible complications related to HIT. (151/250 words).
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Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Pulmonary Embolism
/
Respiratory Insufficiency
/
Thrombocytopenia
/
Thrombosis
/
COVID-19 Drug Treatment
Тип исследования:
История болезни
/
Диагностическое исследование
/
Прогностическое исследование
Темы:
Длинный Ковид
Пределы темы:
Люди
/
Мужчины
/
Middle aged
Язык:
английский
Журнал:
J Infect Chemother
Тематика журнала:
Микробиология
/
Лекарственная терапия
Год:
2022
Тип:
Статья
Аффилированная страна:
J.jiac.2022.05.001
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