Your browser doesn't support javascript.
Promising Antimycobacterial Activities of Flavonoids against Mycobacterium sp. Drug Targets: A Comprehensive Review.
Rabaan, Ali A; Alhumaid, Saad; Albayat, Hawra; Alsaeed, Mohammed; Alofi, Fadwa S; Al-Howaidi, Mawaheb H; Turkistani, Safaa A; Alhajri, Salah M; Alahmed, Hejji E; Alzahrani, Abdulwahab B; Mashraqi, Mutaib M; Alwarthan, Sara; Alhajri, Mashael; Alshahrani, Fatimah S; Almuthree, Souad A; Alsubki, Roua A; Abuzaid, Abdulmonem A; Alfaresi, Mubarak; Al Fares, Mona A; Mutair, Abbas Al.
  • Rabaan AA; Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.
  • Alhumaid S; College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
  • Albayat H; Department of Public Health and Nutrition, The University of Haripur, Haripur 22610, Pakistan.
  • Alsaeed M; Administration of Pharmaceutical Care, Al-Ahsa Health Cluster, Ministry of Health, Al-Ahsa 31982, Saudi Arabia.
  • Alofi FS; Infectious Disease Department, King Saud Medical City, Riyadh 7790, Saudi Arabia.
  • Al-Howaidi MH; Infectious Disease Division, Department of Medicine, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia.
  • Turkistani SA; Department of Infectious Diseases, King Fahad Hospital, Madinah 42351, Saudi Arabia.
  • Alhajri SM; Clinical Microbiology Division, Medical Laboratory Department, Qatif Health Network, Qatif 31911, Saudi Arabia.
  • Alahmed HE; Fakeeh College for Medical Science, Jeddah 21134, Saudi Arabia.
  • Alzahrani AB; Infectious and Zoonotic Diseases Division, Ministry of Environment, Water and Agriculture, Al-Ahsa 11116, Saudi Arabia.
  • Mashraqi MM; Department of Laboratory and Blood Bank, King Fahad Hospital, Al Hofuf 36441, Saudi Arabia.
  • Alwarthan S; Molecular Diagnostic Laboratory, King Fahad Armed Forces Hospital, Jeddah 21159, Saudi Arabia.
  • Alhajri M; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran 61441, Saudi Arabia.
  • Alshahrani FS; Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia.
  • Almuthree SA; Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia.
  • Alsubki RA; Department of Internal Medicine, College of Medicine, King Saud University, Riyadh 11362, Saudi Arabia.
  • Abuzaid AA; Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, King Saud University and King Saud University Medical City, Riyadh 11451, Saudi Arabia.
  • Alfaresi M; Department of Infectious Disease, King Abdullah Medical City, Makkah 43442, Saudi Arabia.
  • Al Fares MA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11362, Saudi Arabia.
  • Mutair AA; Medical Microbiology Department, Security Forces Hospital Programme, Dammam 32314, Saudi Arabia.
Molecules ; 27(16)2022 Aug 22.
Статья в английский | MEDLINE | ID: covidwho-2023940
ABSTRACT
Tuberculosis (TB) caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb) remains a threat to mankind, with over a billion of deaths in the last two centuries. Recent advancements in science have contributed to an understanding of Mtb pathogenesis and developed effective control tools, including effective drugs to control the global pandemic. However, the emergence of drug resistant Mtb strains has seriously affected the TB eradication program around the world. There is, therefore, an urgent need to develop new drugs for TB treatment, which has grown researchers' interest in small molecule-based drug designing and development. The small molecules-based treatments hold significant potential to overcome drug resistance and even provide opportunities for multimodal therapy. In this context, various natural and synthetic flavonoids were reported for the effective treatment of TB. In this review, we have summarized the recent advancement in the understanding of Mtb pathogenesis and the importance of both natural and synthetic flavonoids against Mtb infection studied using in vitro and in silico methods. We have also included flavonoids that are able to inhibit the growth of non-tubercular mycobacterial organisms. Hence, understanding the therapeutic properties of flavonoids can be useful for the future treatment of TB.
Тема - темы
ключевые слова

Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Tuberculosis / Mycobacterium tuberculosis Пределы темы: Люди Язык: английский Тематика журнала: Биология Год: 2022 Тип: Статья Аффилированная страна: Molecules27165335

Документы, близкие по теме

MEDLINE

...
LILACS

LIS


Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Tuberculosis / Mycobacterium tuberculosis Пределы темы: Люди Язык: английский Тематика журнала: Биология Год: 2022 Тип: Статья Аффилированная страна: Molecules27165335