Genetic Determinants of the Acute Respiratory Distress Syndrome.
J Clin Med
; 12(11)2023 May 27.
Статья
в английский
| MEDLINE | ID: covidwho-20243363
ABSTRACT
Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that arises from multiple causes, including sepsis, pneumonia, trauma, and severe coronavirus disease 2019 (COVID-19). Given the heterogeneity of causes and the lack of specific therapeutic options, it is crucial to understand the genetic and molecular mechanisms that underlie this condition. The identification of genetic risks and pharmacogenetic loci, which are involved in determining drug responses, could help enhance early patient diagnosis, assist in risk stratification of patients, and reveal novel targets for pharmacological interventions, including possibilities for drug repositioning. Here, we highlight the basis and importance of the most common genetic approaches to understanding the pathogenesis of ARDS and its critical triggers. We summarize the findings of screening common genetic variation via genome-wide association studies and analyses based on other approaches, such as polygenic risk scores, multi-trait analyses, or Mendelian randomization studies. We also provide an overview of results from rare genetic variation studies using Next-Generation Sequencing techniques and their links with inborn errors of immunity. Lastly, we discuss the genetic overlap between severe COVID-19 and ARDS by other causes.
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Коллекция:
Международные базы данных
база данных:
MEDLINE
Тип исследования:
Диагностическое исследование
/
Экспериментальные исследования
/
Прогностическое исследование
Язык:
английский
Год:
2023
Тип:
Статья
Аффилированная страна:
Jcm12113713
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