Brain neuronal and glial damage during acute COVID-19 infection in absence of clinical neurological manifestations.
J Neurol Neurosurg Psychiatry
; 93(12): 1343-1348, 2022 Dec.
Статья
в английский
| MEDLINE | ID: covidwho-2038335
ABSTRACT
BACKGROUND:
To assess whether SARS-CoV-2 infection may affect the central nervous system, specifically neurons and glia cells, even without clinical neurological involvement.METHODS:
In this single centre prospective study, serum levels of neurofilament light chain (sNfL) and glial fibrillar acidic protein (sGFAp) were assessed using SimoaTM assay Neurology 2-Plex B Assay Kit, in 148 hospitalised patients with COVID-19 without clinical neurological manifestations and compared them to 53 patients with interstitial pulmonary fibrosis (IPF) and 108 healthy controls (HCs).RESULTS:
Age and sex-corrected sNfL levels were higher in patients with COVID-19 (median log10-sNfL 1.41; IQR 1.04-1.83) than patients with IPF (median log10-sNfL 1.18; IQR 0.98-1.38; p<0.001) and HCs (median log10-sNfL 0.89; IQR 0.72-1.14; p<0.001). Likewise, age and sex-corrected sGFAP levels were higher in patients with COVID-19 (median log10-sGFAP 2.26; IQR 2.02-2.53) in comparison with patients with IPF (median log10-sGFAP 2.15; IQR 1.94-2.30; p<0.001) and HCs (median log10-sGFAP 1.87; IQR 0.64-2.09; p<0.001). No significant difference was found between patients with HCs and IPF (p=0.388 for sNfL and p=0.251 for sGFAp). In patients with COVID-19, a prognostic model with mortality as dependent variable (26/148 patients died during hospitalisation) and sNfl, sGFAp and age as independent variables, showed an area under curve of 0.72 (95% CI 0.59 to 0.84; negative predictive value (NPV) (%)80,positive predictive value (PPV)(%) 84; p=0.0008).CONCLUSION:
The results of our study suggest that neuronal and glial degeneration can occur in patients with COVID-19 regardless of overt clinical neurological manifestations. With age, levels of sNfl and GFAp can predict in-hospital COVID-19-associated mortality and might be useful to assess COVID-19 patient prognostic profile.ключевые слова
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Brain
/
Neuroglia
/
COVID-19
/
Neurons
Тип исследования:
Когортное исследование
/
Наблюдательное исследование
/
Прогностическое исследование
Пределы темы:
Женщины
/
Люди
/
Мужчины
Язык:
английский
Журнал:
J Neurol Neurosurg Psychiatry
Год:
2022
Тип:
Статья
Аффилированная страна:
Jnnp-2022-329933
Документы, близкие по теме
MEDLINE
...
LILACS
LIS