Usefulness of KL-6 for Predicting Clinical Outcomes in Hospitalized COVID-19 Patients.
Medicina (Kaunas)
; 58(10)2022 Sep 21.
Статья
в английский
| MEDLINE | ID: covidwho-2043859
ABSTRACT
Background:
Krebs von den Lungen 6 (KL-6) is a novel biomarker for interstitial lung disease, and it reflects acute lung injury. We explored the usefulness of KL-6 to predict clinical outcomes in hospitalized coronavirus disease 2019 (COVID-19) patients.Methods:
In a total of 48 hospitalized COVID-19 patients, KL-6 levels were measured using the HISCL KL-6 assay (Sysmex, Kobe, Japan) with the HISCL 5000 automated analyzer (Sysmex). Clinical outcomes (intensive care unit [ICU] admission, ventilator use, extracorporeal membrane oxygenation [ECMO] use, and 30-day mortality) were analyzed according to KL-6 percentiles. Age, initial KL-6 level, Charlson comorbidity index (CCI), and critical disease were compared using the receiver operating characteristic (ROC) curve and Kaplan-Meier methods for clinical outcomes.Results:
KL-6 quartiles were associated with ICU admission, ventilator use, and ECMO use (all p < 0.05), except 30-day mortality (p = 0.187). On ROC curve analysis, initial KL-6 level predicted ICU admission, ventilator use, and ECMO use significantly better than age, CCI, and critical disease (all p < 0.05); age, initial KL-6 level, CCI, and critical disease predicted 30-day mortality comparably. On Kaplan-Meier survival analysis, hazard ratios (95% confidence interval) were 4.8 (1.2-19.3) for age, 4.7 (1.1-21.6) for initial KL-6 level, 3.9 (0.9-16.2) for CCI, and 2.1 (0.5-10.3) for critical disease.Conclusions:
This study demonstrated that KL-6 could be a useful biomarker to predict clinical outcomes in hospitalized COVID-19 patients. KL-6 may contribute to identifying COVID-19 patients requiring critical care, including ICU admission and ventilator and/or ECMO use.ключевые слова
Полный текст:
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Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Lung Diseases, Interstitial
/
COVID-19
Тип исследования:
Наблюдательное исследование
/
Прогностическое исследование
Пределы темы:
Детский дошкольный
/
Люди
Страна как тема:
Азия
Язык:
английский
Тематика журнала:
Медицина
Год:
2022
Тип:
Статья
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